RNA Modifications Meet Tumors
Zhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/rna-modifications-meet-tumors-peer-reviewed-fulltext-article-CMAR |
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| author | Yang Z Zhang S Xia T Fan Y Shan Y Zhang K Xiong J Gu M You B |
| author_facet | Yang Z Zhang S Xia T Fan Y Shan Y Zhang K Xiong J Gu M You B |
| author_sort | Yang Z |
| collection | DOAJ |
| description | Zhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People’s Republic of China; 2Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo You; Miao Gu, Email youbo19891014@163.com; 13862932120@163.comAbstract: RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell “internet”, etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N6-methyladenine (m6A), 5-methylcytosine (m5C), N7-methyladenosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors.Keywords: tumor, RNA modification, non-coding RNA, tumor microenvironment, tumor therapy |
| first_indexed | 2024-04-12T06:28:51Z |
| format | Article |
| id | doaj.art-1aefeb8376534a9a9b052504455aaf57 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-12T06:28:51Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-1aefeb8376534a9a9b052504455aaf572022-12-22T03:44:03ZengDove Medical PressCancer Management and Research1179-13222022-11-01Volume 143223324379818RNA Modifications Meet TumorsYang ZZhang SXia TFan YShan YZhang KXiong JGu MYou BZhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People’s Republic of China; 2Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo You; Miao Gu, Email youbo19891014@163.com; 13862932120@163.comAbstract: RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell “internet”, etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N6-methyladenine (m6A), 5-methylcytosine (m5C), N7-methyladenosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors.Keywords: tumor, RNA modification, non-coding RNA, tumor microenvironment, tumor therapyhttps://www.dovepress.com/rna-modifications-meet-tumors-peer-reviewed-fulltext-article-CMARtumorrna modificationnon-coding rnatumor microenvironmenttumor therapy |
| spellingShingle | Yang Z Zhang S Xia T Fan Y Shan Y Zhang K Xiong J Gu M You B RNA Modifications Meet Tumors Cancer Management and Research tumor rna modification non-coding rna tumor microenvironment tumor therapy |
| title | RNA Modifications Meet Tumors |
| title_full | RNA Modifications Meet Tumors |
| title_fullStr | RNA Modifications Meet Tumors |
| title_full_unstemmed | RNA Modifications Meet Tumors |
| title_short | RNA Modifications Meet Tumors |
| title_sort | rna modifications meet tumors |
| topic | tumor rna modification non-coding rna tumor microenvironment tumor therapy |
| url | https://www.dovepress.com/rna-modifications-meet-tumors-peer-reviewed-fulltext-article-CMAR |
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