Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients
Background: High sensitive C-reactive protein (hs-CRP) and eosinophilic cationic protein (ECP) have been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet. Patients and methods: Thirty patients...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-10-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763814001514 |
| _version_ | 1818539405487374336 |
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| author | Ashraf E. Sileem Sameh Embarak Mahmoud S. Meleha |
| author_facet | Ashraf E. Sileem Sameh Embarak Mahmoud S. Meleha |
| author_sort | Ashraf E. Sileem |
| collection | DOAJ |
| description | Background: High sensitive C-reactive protein (hs-CRP) and eosinophilic cationic protein (ECP) have been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet.
Patients and methods: Thirty patients with newly-diagnosed bronchial asthma and 20 healthy individuals were enrolled in this study. In addition to medical history and physical examination, asthma was assessed according to the Global Initiative for Asthma (GINA) guidelines. Respiratory function tests (RFT), serum hs-CRP and ECP levels, serum total IgE levels, circulating eosinophil count (CE) and asthma control test (ACT) were performed for all subjects.
Results: Serum ECP, serum hs-CRP, serum total IgE and CE were significantly higher (p < 0.01, 0.01, 0.05 and 0.05, respectively), while forced expiratory volume in 1 s (FEV1 %) and ACT were significantly lower (p < 0.05) in asthmatic patients compared to the control group. In all patients with bronchial asthma, serum levels of hs-CRP and ECP showed significant positive correlations with asthma severity (hs-CRP, rs = 0.59, p < 0.01; ECP, rs = 0.63, p < 0.01, respectively) but, significant negative correlations with ACT (hs-CRP, rs = −0.53, p < 0.05; ECP, rs = −0.62, p < 0.01, respectively) and FEV1 % (hs-CRP, rs = −0.46, p < 0.05; ECP, rs = −0.57, p < 0.01, respectively). Serum ECP and hs-CRP levels showed significant fall (p < 0.01and p < 0.05, respectively), while, FEV1 % and ACT showed significant increase (p < 0.05) in asthmatic patients who were followed up after 2 months of therapy.
Conclusion: Coupling measurements of serum levels of both ECP and hs-CRP may add a benefit in determining the severity and monitoring of the control of bronchial asthma. |
| first_indexed | 2024-12-11T21:41:36Z |
| format | Article |
| id | doaj.art-1aeffda92b58408b97f97a58364b7a6c |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-11T21:41:36Z |
| publishDate | 2014-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-1aeffda92b58408b97f97a58364b7a6c2022-12-22T00:49:49ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382014-10-0163476577010.1016/j.ejcdt.2014.07.001Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patientsAshraf E. Sileem0Sameh Embarak1Mahmoud S. Meleha2Chest Department, Zagazig University, EgyptChest Department, Zagazig University, EgyptClinical Pathology Department, Ainshams University, EgyptBackground: High sensitive C-reactive protein (hs-CRP) and eosinophilic cationic protein (ECP) have been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet. Patients and methods: Thirty patients with newly-diagnosed bronchial asthma and 20 healthy individuals were enrolled in this study. In addition to medical history and physical examination, asthma was assessed according to the Global Initiative for Asthma (GINA) guidelines. Respiratory function tests (RFT), serum hs-CRP and ECP levels, serum total IgE levels, circulating eosinophil count (CE) and asthma control test (ACT) were performed for all subjects. Results: Serum ECP, serum hs-CRP, serum total IgE and CE were significantly higher (p < 0.01, 0.01, 0.05 and 0.05, respectively), while forced expiratory volume in 1 s (FEV1 %) and ACT were significantly lower (p < 0.05) in asthmatic patients compared to the control group. In all patients with bronchial asthma, serum levels of hs-CRP and ECP showed significant positive correlations with asthma severity (hs-CRP, rs = 0.59, p < 0.01; ECP, rs = 0.63, p < 0.01, respectively) but, significant negative correlations with ACT (hs-CRP, rs = −0.53, p < 0.05; ECP, rs = −0.62, p < 0.01, respectively) and FEV1 % (hs-CRP, rs = −0.46, p < 0.05; ECP, rs = −0.57, p < 0.01, respectively). Serum ECP and hs-CRP levels showed significant fall (p < 0.01and p < 0.05, respectively), while, FEV1 % and ACT showed significant increase (p < 0.05) in asthmatic patients who were followed up after 2 months of therapy. Conclusion: Coupling measurements of serum levels of both ECP and hs-CRP may add a benefit in determining the severity and monitoring of the control of bronchial asthma.http://www.sciencedirect.com/science/article/pii/S0422763814001514Eosinophilic cationic proteinHigh sensitive C-reactive proteinBronchial asthma |
| spellingShingle | Ashraf E. Sileem Sameh Embarak Mahmoud S. Meleha Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients Egyptian Journal of Chest Disease and Tuberculosis Eosinophilic cationic protein High sensitive C-reactive protein Bronchial asthma |
| title | Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| title_full | Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| title_fullStr | Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| title_full_unstemmed | Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| title_short | Serum eosinophilic cationic protein and high sensitive C-reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| title_sort | serum eosinophilic cationic protein and high sensitive c reactive protein as alternative parameters for differentiation of severity stages and monitoring control in bronchial asthma patients |
| topic | Eosinophilic cationic protein High sensitive C-reactive protein Bronchial asthma |
| url | http://www.sciencedirect.com/science/article/pii/S0422763814001514 |
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