MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
<p>Abstract</p> <p>MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals wer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-12-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/5/1/118 |
| Summary: | <p>Abstract</p> <p>MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.</p> |
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| ISSN: | 1742-4690 |