A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor
Energy metabolism is a fundamental process in all organisms. During silkworm (<i>Bombyx mori</i>) embryonic development, there is a high demand for energy due to continuous cell proliferation and differentiation. Estrogen-related receptors (ERRs) are transcriptional regulatory factors th...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14485 |
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| author | Guanwang Shen Die Liu Haoran Xu Jinxin Wu Luyu Hou Chunyan Yang Qingyou Xia Ping Lin |
| author_facet | Guanwang Shen Die Liu Haoran Xu Jinxin Wu Luyu Hou Chunyan Yang Qingyou Xia Ping Lin |
| author_sort | Guanwang Shen |
| collection | DOAJ |
| description | Energy metabolism is a fundamental process in all organisms. During silkworm (<i>Bombyx mori</i>) embryonic development, there is a high demand for energy due to continuous cell proliferation and differentiation. Estrogen-related receptors (ERRs) are transcriptional regulatory factors that play crucial roles in mammalian energy storage and expenditure. Although most insects have one ERR gene, it also participates in the regulation of energy metabolism, including carbohydrate metabolism in <i>Drosophila</i>, <i>Aphid</i>, and <i>Silkworm</i>. However, no study has reported the direct impact of energy metabolism on embryonic development in silkworms. In this study, we used transgenic technology to increase silkworm (<i>B. mori</i>; Bm) BmERR expression during embryonic development and explored the impact of energy on embryonic development. We found no significant change in the quality of silkworm eggs compared to that of wild-type silkworms. However, there was an increase in the consumption of vitellin, a major nutrient in embryos. This resulted in a decrease in glucose content and a significant increase in ATP content. These findings provide evidence that the acceleration of energy metabolism promotes embryonic development and enhances the motility of hatched silkworms. In addition, these results provide a novel perspective on the relationship between energy metabolism and embryonic development in other insects. |
| first_indexed | 2024-03-10T21:43:23Z |
| format | Article |
| id | doaj.art-1af2043d51644588b6ec366050e5196c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:23Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1af2043d51644588b6ec366050e5196c2023-11-19T14:27:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191448510.3390/ijms241914485A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related ReceptorGuanwang Shen0Die Liu1Haoran Xu2Jinxin Wu3Luyu Hou4Chunyan Yang5Qingyou Xia6Ping Lin7Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaIntegrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, ChinaEnergy metabolism is a fundamental process in all organisms. During silkworm (<i>Bombyx mori</i>) embryonic development, there is a high demand for energy due to continuous cell proliferation and differentiation. Estrogen-related receptors (ERRs) are transcriptional regulatory factors that play crucial roles in mammalian energy storage and expenditure. Although most insects have one ERR gene, it also participates in the regulation of energy metabolism, including carbohydrate metabolism in <i>Drosophila</i>, <i>Aphid</i>, and <i>Silkworm</i>. However, no study has reported the direct impact of energy metabolism on embryonic development in silkworms. In this study, we used transgenic technology to increase silkworm (<i>B. mori</i>; Bm) BmERR expression during embryonic development and explored the impact of energy on embryonic development. We found no significant change in the quality of silkworm eggs compared to that of wild-type silkworms. However, there was an increase in the consumption of vitellin, a major nutrient in embryos. This resulted in a decrease in glucose content and a significant increase in ATP content. These findings provide evidence that the acceleration of energy metabolism promotes embryonic development and enhances the motility of hatched silkworms. In addition, these results provide a novel perspective on the relationship between energy metabolism and embryonic development in other insects.https://www.mdpi.com/1422-0067/24/19/14485estrogen-related receptorenergyembryonic developmenttransgenic silkworm |
| spellingShingle | Guanwang Shen Die Liu Haoran Xu Jinxin Wu Luyu Hou Chunyan Yang Qingyou Xia Ping Lin A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor International Journal of Molecular Sciences estrogen-related receptor energy embryonic development transgenic silkworm |
| title | A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor |
| title_full | A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor |
| title_fullStr | A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor |
| title_full_unstemmed | A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor |
| title_short | A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor |
| title_sort | study on the effect of energy on the development of silkworm embryos using an estrogen related receptor |
| topic | estrogen-related receptor energy embryonic development transgenic silkworm |
| url | https://www.mdpi.com/1422-0067/24/19/14485 |
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