Vinyl thianthrenium-mediated cysteine bioconjugation
Covalent cysteine labeling is an important tool in protein modification, however, current methodologies suffer from limited reactivities and require the prior synthesis of individual derivative reagents. Now, a covalent cysteine labeling method that converts the cysteinyl thiol into episulfonium ele...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-024-01111-8 |
| _version_ | 1797275531294539776 |
|---|---|
| author | Huijuan Guo |
| author_facet | Huijuan Guo |
| author_sort | Huijuan Guo |
| collection | DOAJ |
| description | Covalent cysteine labeling is an important tool in protein modification, however, current methodologies suffer from limited reactivities and require the prior synthesis of individual derivative reagents. Now, a covalent cysteine labeling method that converts the cysteinyl thiol into episulfonium electrophiles in situ has been developed, enabling reactions with various nucleophiles in one step. |
| first_indexed | 2024-03-07T15:15:48Z |
| format | Article |
| id | doaj.art-1af302a830134befa6cfb3898f7c969d |
| institution | Directory Open Access Journal |
| issn | 2399-3669 |
| language | English |
| last_indexed | 2024-03-07T15:15:48Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Chemistry |
| spelling | doaj.art-1af302a830134befa6cfb3898f7c969d2024-03-05T17:55:37ZengNature PortfolioCommunications Chemistry2399-36692024-02-01711210.1038/s42004-024-01111-8Vinyl thianthrenium-mediated cysteine bioconjugationHuijuan Guo0Communications ChemistryCovalent cysteine labeling is an important tool in protein modification, however, current methodologies suffer from limited reactivities and require the prior synthesis of individual derivative reagents. Now, a covalent cysteine labeling method that converts the cysteinyl thiol into episulfonium electrophiles in situ has been developed, enabling reactions with various nucleophiles in one step.https://doi.org/10.1038/s42004-024-01111-8 |
| spellingShingle | Huijuan Guo Vinyl thianthrenium-mediated cysteine bioconjugation Communications Chemistry |
| title | Vinyl thianthrenium-mediated cysteine bioconjugation |
| title_full | Vinyl thianthrenium-mediated cysteine bioconjugation |
| title_fullStr | Vinyl thianthrenium-mediated cysteine bioconjugation |
| title_full_unstemmed | Vinyl thianthrenium-mediated cysteine bioconjugation |
| title_short | Vinyl thianthrenium-mediated cysteine bioconjugation |
| title_sort | vinyl thianthrenium mediated cysteine bioconjugation |
| url | https://doi.org/10.1038/s42004-024-01111-8 |
| work_keys_str_mv | AT huijuanguo vinylthianthreniummediatedcysteinebioconjugation |