The role of group 3 innate lymphoid cell in intestinal disease
Group 3 innate lymphoid cells (ILC3s), a novel subpopulation of lymphocytes enriched in the intestinal mucosa, are currently considered as key sentinels in maintaining intestinal immune homeostasis. ILC3s can secrete a series of cytokines such as IL-22 to eliminate intestinal luminal antigens, promo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171826/full |
| _version_ | 1797847140933828608 |
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| author | Minghui Li Zehui Wang Wei Jiang Yihan Lu Jun Zhang |
| author_facet | Minghui Li Zehui Wang Wei Jiang Yihan Lu Jun Zhang |
| author_sort | Minghui Li |
| collection | DOAJ |
| description | Group 3 innate lymphoid cells (ILC3s), a novel subpopulation of lymphocytes enriched in the intestinal mucosa, are currently considered as key sentinels in maintaining intestinal immune homeostasis. ILC3s can secrete a series of cytokines such as IL-22 to eliminate intestinal luminal antigens, promote epithelial tissue repair and mucosal barrier integrity, and regulate intestinal immunity by integrating multiple signals from the environment and the host. However, ILC3 dysfunction may be associated with the development and progression of various diseases in the gut. Therefore, in this review, we will discuss the role of ILC3 in intestinal diseases such as enteric infectious diseases, intestinal inflammation, and tumors, with a focus on recent research advances and discoveries to explore potential therapeutic targets. |
| first_indexed | 2024-04-09T18:06:23Z |
| format | Article |
| id | doaj.art-1af3150d2ae846c786175670ea8f56e2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T18:06:23Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1af3150d2ae846c786175670ea8f56e22023-04-14T05:36:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11718261171826The role of group 3 innate lymphoid cell in intestinal diseaseMinghui LiZehui WangWei JiangYihan LuJun ZhangGroup 3 innate lymphoid cells (ILC3s), a novel subpopulation of lymphocytes enriched in the intestinal mucosa, are currently considered as key sentinels in maintaining intestinal immune homeostasis. ILC3s can secrete a series of cytokines such as IL-22 to eliminate intestinal luminal antigens, promote epithelial tissue repair and mucosal barrier integrity, and regulate intestinal immunity by integrating multiple signals from the environment and the host. However, ILC3 dysfunction may be associated with the development and progression of various diseases in the gut. Therefore, in this review, we will discuss the role of ILC3 in intestinal diseases such as enteric infectious diseases, intestinal inflammation, and tumors, with a focus on recent research advances and discoveries to explore potential therapeutic targets.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171826/fullinnate lymphoid cellintestinal immunityinflammatory bowel diseasecolorectal cancerimmune therapyplasticity |
| spellingShingle | Minghui Li Zehui Wang Wei Jiang Yihan Lu Jun Zhang The role of group 3 innate lymphoid cell in intestinal disease Frontiers in Immunology innate lymphoid cell intestinal immunity inflammatory bowel disease colorectal cancer immune therapy plasticity |
| title | The role of group 3 innate lymphoid cell in intestinal disease |
| title_full | The role of group 3 innate lymphoid cell in intestinal disease |
| title_fullStr | The role of group 3 innate lymphoid cell in intestinal disease |
| title_full_unstemmed | The role of group 3 innate lymphoid cell in intestinal disease |
| title_short | The role of group 3 innate lymphoid cell in intestinal disease |
| title_sort | role of group 3 innate lymphoid cell in intestinal disease |
| topic | innate lymphoid cell intestinal immunity inflammatory bowel disease colorectal cancer immune therapy plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171826/full |
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