Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells

Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells

Background: Male infertility is a worldwide problem but few treatments, especially irradiation-induced testicular injury. The aim of this research was to investigate novel drugs for the treatment of irradiation-induced testicular injury. Methods: We administered dibucaine (0.8 mg/kg) intraperitoneal...

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Bibliographic Details
Main Authors:	Lingxiang Ran, Qiu Chen, Xingyu Lu, Zhixiang Gao, Fengmei Cui, Xiaolong Liu, Boxin Xue
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Testicular injury Dibucaine Irradiation Drug affinity responsive target stability (Darts) Primary Leydig cells Mitochondrial fatty acid oxidation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223006935

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