Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance
Thrombocytopenia (less than 100 × 10 9 /L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component of insulin resistance (IR). It is unknown whether IR, by itself, associates with thrombocytopenia. Persons with NAFLD and/or IR were pr...
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Format: | Article |
Language: | English |
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SAGE Publishing
2019-12-01
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Series: | Clinical and Applied Thrombosis/Hemostasis |
Online Access: | https://doi.org/10.1177/1076029619888694 |
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author | Miguel Antonio López-Trujillo Bsc Jesús Mauricio Olivares-Gazca MD Yahveth Cantero-Fortiz MD Yarely Itzayana García-Navarrete MD Antonio Cruz-Mora MD Juan Carlos Olivares-Gazca MD Iván Murrieta-Álvarez MD Andrés Aurelio León-Peña MD Guillermo J. Ruiz-Delgado MD, FACP Guillermo J. Ruiz-Argüelles MD, FACP FRCP (Glasg), MACP, DSc (hon) |
author_facet | Miguel Antonio López-Trujillo Bsc Jesús Mauricio Olivares-Gazca MD Yahveth Cantero-Fortiz MD Yarely Itzayana García-Navarrete MD Antonio Cruz-Mora MD Juan Carlos Olivares-Gazca MD Iván Murrieta-Álvarez MD Andrés Aurelio León-Peña MD Guillermo J. Ruiz-Delgado MD, FACP Guillermo J. Ruiz-Argüelles MD, FACP FRCP (Glasg), MACP, DSc (hon) |
author_sort | Miguel Antonio López-Trujillo Bsc |
collection | DOAJ |
description | Thrombocytopenia (less than 100 × 10 9 /L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component of insulin resistance (IR). It is unknown whether IR, by itself, associates with thrombocytopenia. Persons with NAFLD and/or IR were prospectively accrued in the study after February 2018. Insulin resistance was defined by assessing α hydroxybutyrate, lynoleoyl glycerolphosphocoline, oleic acid, and insulin (Quantose IR), whereas the presence of NAFLD was defined by serologic determinations (Fibromax) and liver transient elastography (Fibroscan). In 78 patients with NAFLD, thrombocytopenia was identified in 22 (28%), whereas in 19 persons with IR, 14 (73%) were found to have NAFLD. In persons with IR + NAFLD, thrombocytopenia presented in 9 (64%). In the subset of patients with IR, the prevalence of thrombocytopenia was 52%. There was only 1 patient with IR/without NAFLD who displayed thrombocytopenia. Significant statistical association between NAFLD and thrombocytopenia was found (odds ratio [OR]: = 13, confidence interval [CI]: 1.5-162, P = .05), whereas there was no association between IR and thrombocytopenia (OR = 0.38, CI: 0.06-2.3, P = .61). Insulin resistance, by itself, was not found to be associated with diminished platelet counts. The presence of NAFLD, one of the consequences of IR, seems to be required to lead into thrombocytopenia. |
first_indexed | 2024-04-13T05:23:40Z |
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institution | Directory Open Access Journal |
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language | English |
last_indexed | 2024-04-13T05:23:40Z |
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publisher | SAGE Publishing |
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series | Clinical and Applied Thrombosis/Hemostasis |
spelling | doaj.art-1af3c1b0ff2647e987f52c2c0231dfcf2022-12-22T03:00:39ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232019-12-012510.1177/1076029619888694Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin ResistanceMiguel Antonio López-Trujillo Bsc0Jesús Mauricio Olivares-Gazca MD1Yahveth Cantero-Fortiz MD2Yarely Itzayana García-Navarrete MD3Antonio Cruz-Mora MD4Juan Carlos Olivares-Gazca MD5Iván Murrieta-Álvarez MD6Andrés Aurelio León-Peña MD7Guillermo J. Ruiz-Delgado MD, FACP8Guillermo J. Ruiz-Argüelles MD, FACP FRCP (Glasg), MACP, DSc (hon)9 Laboratorios Clínicos de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Universidad de las Américas Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Benemérita Universidad Autónoma de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico Centro de Hematología y Medicina Interna de Puebla, Puebla, MexicoThrombocytopenia (less than 100 × 10 9 /L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component of insulin resistance (IR). It is unknown whether IR, by itself, associates with thrombocytopenia. Persons with NAFLD and/or IR were prospectively accrued in the study after February 2018. Insulin resistance was defined by assessing α hydroxybutyrate, lynoleoyl glycerolphosphocoline, oleic acid, and insulin (Quantose IR), whereas the presence of NAFLD was defined by serologic determinations (Fibromax) and liver transient elastography (Fibroscan). In 78 patients with NAFLD, thrombocytopenia was identified in 22 (28%), whereas in 19 persons with IR, 14 (73%) were found to have NAFLD. In persons with IR + NAFLD, thrombocytopenia presented in 9 (64%). In the subset of patients with IR, the prevalence of thrombocytopenia was 52%. There was only 1 patient with IR/without NAFLD who displayed thrombocytopenia. Significant statistical association between NAFLD and thrombocytopenia was found (odds ratio [OR]: = 13, confidence interval [CI]: 1.5-162, P = .05), whereas there was no association between IR and thrombocytopenia (OR = 0.38, CI: 0.06-2.3, P = .61). Insulin resistance, by itself, was not found to be associated with diminished platelet counts. The presence of NAFLD, one of the consequences of IR, seems to be required to lead into thrombocytopenia.https://doi.org/10.1177/1076029619888694 |
spellingShingle | Miguel Antonio López-Trujillo Bsc Jesús Mauricio Olivares-Gazca MD Yahveth Cantero-Fortiz MD Yarely Itzayana García-Navarrete MD Antonio Cruz-Mora MD Juan Carlos Olivares-Gazca MD Iván Murrieta-Álvarez MD Andrés Aurelio León-Peña MD Guillermo J. Ruiz-Delgado MD, FACP Guillermo J. Ruiz-Argüelles MD, FACP FRCP (Glasg), MACP, DSc (hon) Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance Clinical and Applied Thrombosis/Hemostasis |
title | Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance |
title_full | Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance |
title_fullStr | Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance |
title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance |
title_short | Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance |
title_sort | nonalcoholic fatty liver disease and thrombocytopenia iii its association with insulin resistance |
url | https://doi.org/10.1177/1076029619888694 |
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