Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing

Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and IκB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing

The non-neuronal and non-muscular effects of botulinum toxin type A (BTXA) on scar reduction has been discovered. This study was designed to investigate the effects of BTXA on macrophages polarization during the early stage of skin repair. A skin defect model was established on the dorsal skin of SD...

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Bibliographic Details
Main Authors: Yan-ping Zou, Xiao-feng Shan, Jia-xuan Qiu, Lin-na Wang, Ruo-lan Xiang, Zhi-gang Cai
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Botulinum toxin type A
Scar formation
M1 macrophage
Inflammation
Wound healing
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003524

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