Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation

Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation

Clr4 is a histone H3 lysine 9 methyltransferase in <i>Schizosaccharomyces pombe</i> that is essential for heterochromatin formation. Previous biochemical and structural studies have shown that Clr4 is in an autoinhibited state in which an autoregulatory loop (ARL) blocks the active site....

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Bibliographic Details
Main Authors: Mina S. Khella, Alexander Bröhm, Sara Weirich, Albert Jeltsch
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
protein methylation
protein methyltransferase
automethylation
enzyme regulation
enzyme kinetics
Online Access:https://www.mdpi.com/1422-0067/21/22/8832

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