Host-mediated RNA editing in viruses
Abstract Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | Biology Direct |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13062-023-00366-w |
| _version_ | 1797853967626010624 |
|---|---|
| author | Tongtong Zhu Guangyi Niu Yuansheng Zhang Ming Chen Chuan-Yun Li Lili Hao Zhang Zhang |
| author_facet | Tongtong Zhu Guangyi Niu Yuansheng Zhang Ming Chen Chuan-Yun Li Lili Hao Zhang Zhang |
| author_sort | Tongtong Zhu |
| collection | DOAJ |
| description | Abstract Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses. |
| first_indexed | 2024-04-09T19:59:20Z |
| format | Article |
| id | doaj.art-1af708f5dadf462fa2f6e162afbc5b88 |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-04-09T19:59:20Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-1af708f5dadf462fa2f6e162afbc5b882023-04-03T05:19:34ZengBMCBiology Direct1745-61502023-03-0118111210.1186/s13062-023-00366-wHost-mediated RNA editing in virusesTongtong Zhu0Guangyi Niu1Yuansheng Zhang2Ming Chen3Chuan-Yun Li4Lili Hao5Zhang Zhang6National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesLaboratory of Bioinformatics and Genomic Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking UniversityNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesNational Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of SciencesAbstract Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses.https://doi.org/10.1186/s13062-023-00366-wVirusRNA editingDeaminationProviralAntiviral |
| spellingShingle | Tongtong Zhu Guangyi Niu Yuansheng Zhang Ming Chen Chuan-Yun Li Lili Hao Zhang Zhang Host-mediated RNA editing in viruses Biology Direct Virus RNA editing Deamination Proviral Antiviral |
| title | Host-mediated RNA editing in viruses |
| title_full | Host-mediated RNA editing in viruses |
| title_fullStr | Host-mediated RNA editing in viruses |
| title_full_unstemmed | Host-mediated RNA editing in viruses |
| title_short | Host-mediated RNA editing in viruses |
| title_sort | host mediated rna editing in viruses |
| topic | Virus RNA editing Deamination Proviral Antiviral |
| url | https://doi.org/10.1186/s13062-023-00366-w |
| work_keys_str_mv | AT tongtongzhu hostmediatedrnaeditinginviruses AT guangyiniu hostmediatedrnaeditinginviruses AT yuanshengzhang hostmediatedrnaeditinginviruses AT mingchen hostmediatedrnaeditinginviruses AT chuanyunli hostmediatedrnaeditinginviruses AT lilihao hostmediatedrnaeditinginviruses AT zhangzhang hostmediatedrnaeditinginviruses |