Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient
Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-12-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883221139914 |
| _version_ | 1811204969649405952 |
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| author | Sanda Mrabet Wiem Romdhane Asma Fradi Raja Boukadida Awatef Azzabi Yosra Guedri Wissal Sahtout Narjess BenAicha Nihed Abdessayed Moncef Mokni Dorsaf Zellama Abdellatif Achour |
| author_facet | Sanda Mrabet Wiem Romdhane Asma Fradi Raja Boukadida Awatef Azzabi Yosra Guedri Wissal Sahtout Narjess BenAicha Nihed Abdessayed Moncef Mokni Dorsaf Zellama Abdellatif Achour |
| author_sort | Sanda Mrabet |
| collection | DOAJ |
| description | Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a polyparasitic infection ( Giardia lamblia, Entamoeba coli , and Endolimax nana ) resulting in a severe biopsy-proven AIN in a 61-year-old male patient. Despite the antiparasitic treatment followed by corticosteroid therapy, and during the 6-month follow-up period, the patient remained dialysis-dependent, and he developed autoimmune hemolytic anemia. Extensive search for another infection or neoplasia was negative. Immunological tests were also negative. The resulting hypersensitivity reaction to the triple parasite infection would have led to fatal evolution for the kidneys affected by this unusual type of AIN. |
| first_indexed | 2024-04-12T03:22:41Z |
| format | Article |
| id | doaj.art-1af77d01206c47888512f3bb7cac364b |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-04-12T03:22:41Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-1af77d01206c47888512f3bb7cac364b2022-12-22T03:49:51ZengSAGE PublishingAmerican Journal of Men's Health1557-98912022-12-011610.1177/15579883221139914Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male PatientSanda Mrabet0Wiem Romdhane1Asma Fradi2Raja Boukadida3Awatef Azzabi4Yosra Guedri5Wissal Sahtout6Narjess BenAicha7Nihed Abdessayed8Moncef Mokni9Dorsaf Zellama10Abdellatif Achour11Department of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Pathology, Farhat Hached University Hospital Sousse, Sousse, TunisiaDepartment of Pathology, Farhat Hached University Hospital Sousse, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaDepartment of Nephrology, Dialysis, and Transplantation, Sahloul University Hospital, Sousse, TunisiaAcute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a polyparasitic infection ( Giardia lamblia, Entamoeba coli , and Endolimax nana ) resulting in a severe biopsy-proven AIN in a 61-year-old male patient. Despite the antiparasitic treatment followed by corticosteroid therapy, and during the 6-month follow-up period, the patient remained dialysis-dependent, and he developed autoimmune hemolytic anemia. Extensive search for another infection or neoplasia was negative. Immunological tests were also negative. The resulting hypersensitivity reaction to the triple parasite infection would have led to fatal evolution for the kidneys affected by this unusual type of AIN.https://doi.org/10.1177/15579883221139914 |
| spellingShingle | Sanda Mrabet Wiem Romdhane Asma Fradi Raja Boukadida Awatef Azzabi Yosra Guedri Wissal Sahtout Narjess BenAicha Nihed Abdessayed Moncef Mokni Dorsaf Zellama Abdellatif Achour Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient American Journal of Men's Health |
| title | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
| title_full | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
| title_fullStr | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
| title_full_unstemmed | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
| title_short | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
| title_sort | severe acute interstitial nephritis dermatitis and hemolytic anemia due to polyparasitic infection in an immunocompetent male patient |
| url | https://doi.org/10.1177/15579883221139914 |
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