Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium
To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelacton...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/9/8/1368/ |
| _version_ | 1811187116435046400 |
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| author | Weiming Zhu Peipei Liu Wei Wang Yi Wang Jinkai Zheng |
| author_facet | Weiming Zhu Peipei Liu Wei Wang Yi Wang Jinkai Zheng |
| author_sort | Weiming Zhu |
| collection | DOAJ |
| description | To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4–15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 μM, respectively. |
| first_indexed | 2024-04-11T13:56:46Z |
| format | Article |
| id | doaj.art-1af7f4a4ecb54f00b55c3010b878e1a4 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:56:46Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-1af7f4a4ecb54f00b55c3010b878e1a42022-12-22T04:20:13ZengMDPI AGMarine Drugs1660-33972011-08-01981368137810.3390/md9081368Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt MediumWeiming ZhuPeipei LiuWei WangYi WangJinkai ZhengTo investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4–15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 μM, respectively.http://www.mdpi.com/1660-3397/9/8/1368/Aspergillus terreushigh salinity metabolitesterremides A and Bterrelactone A |
| spellingShingle | Weiming Zhu Peipei Liu Wei Wang Yi Wang Jinkai Zheng Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium Marine Drugs Aspergillus terreus high salinity metabolites terremides A and B terrelactone A |
| title | Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium |
| title_full | Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium |
| title_fullStr | Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium |
| title_full_unstemmed | Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium |
| title_short | Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium |
| title_sort | three new compounds from aspergillus terreus pt06 2 grown in a high salt medium |
| topic | Aspergillus terreus high salinity metabolites terremides A and B terrelactone A |
| url | http://www.mdpi.com/1660-3397/9/8/1368/ |
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