Imatinib activity on Schistosoma mansoni
Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2013-11-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000700850&lng=en&tlng=en |
| _version_ | 1797756689997365248 |
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| author | Naftale Katz Flavia Fernanda Bubulo Couto Neusa Araujo |
| author_facet | Naftale Katz Flavia Fernanda Bubulo Couto Neusa Araujo |
| author_sort | Naftale Katz |
| collection | DOAJ |
| description | Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms. |
| first_indexed | 2024-03-12T18:04:07Z |
| format | Article |
| id | doaj.art-1af8b63f380f46c6b1f9dad860356a50 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:04:07Z |
| publishDate | 2013-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1af8b63f380f46c6b1f9dad860356a502023-08-02T09:29:08ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602013-11-01108785085310.1590/0074-0276130207S0074-02762013000700850Imatinib activity on Schistosoma mansoniNaftale KatzFlavia Fernanda Bubulo CoutoNeusa AraujoImatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000700850&lng=en&tlng=enschistosomiasischemotherapyimatinib |
| spellingShingle | Naftale Katz Flavia Fernanda Bubulo Couto Neusa Araujo Imatinib activity on Schistosoma mansoni Memorias do Instituto Oswaldo Cruz schistosomiasis chemotherapy imatinib |
| title | Imatinib activity on Schistosoma mansoni |
| title_full | Imatinib activity on Schistosoma mansoni |
| title_fullStr | Imatinib activity on Schistosoma mansoni |
| title_full_unstemmed | Imatinib activity on Schistosoma mansoni |
| title_short | Imatinib activity on Schistosoma mansoni |
| title_sort | imatinib activity on schistosoma mansoni |
| topic | schistosomiasis chemotherapy imatinib |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000700850&lng=en&tlng=en |
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