Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury
The aim of the study was to investigate the effect of ethylmethylhydroxypyridine on the ultrastructural alterations in endothelial cells of liver sinusoidal capillaries (SC) and primary hemostasis in the acute phase of traumatic brain injury (TBI).Materials and methods. Ultrastructural endothelial c...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2021-02-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/2014 |
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| author | G. A. Boyarinov O. D. Solovyova E. I. Yakovleva L V. Boyarinova A. V. Deryugina |
| author_facet | G. A. Boyarinov O. D. Solovyova E. I. Yakovleva L V. Boyarinova A. V. Deryugina |
| author_sort | G. A. Boyarinov |
| collection | DOAJ |
| description | The aim of the study was to investigate the effect of ethylmethylhydroxypyridine on the ultrastructural alterations in endothelial cells of liver sinusoidal capillaries (SC) and primary hemostasis in the acute phase of traumatic brain injury (TBI).Materials and methods. Ultrastructural endothelial cell changes were studied in 36 female outbred rats in the acute phase of TBI using electron microscopy, and the platelet count was determined using a blood analyzer. The experimental group (n=18) animals received intraperitoneal injections of ethylmethylhydroxypyridine at the dose of 8.0 mg/kg per day for 12 days, and the control group (n=18) rats were administered with normal saline solution at the same dose.Results. Administration of ethylmethylhydroxypyridine in the early post TBI period reduced microvilli damage in endothelial, hepatic and stellate cells in the Disse space, whereas in the control group a significant decrease of these cells counts was detected. In contrast to the control group, the experimental group animals did not demonstrate thrombocytopenia on the days 1, 3, and 7 after injury. There was a significant increase in the platelet count compared with the baseline values, which was highest on day 12 after injury.Conclusion. Intraperitoneal administration of ethylmethylhydroxypyridine in rats in early post TBI period inhibited the TBI-associated damaging effect of secondary factors on liver sinusoid endothelial cells and platelet consumption. |
| first_indexed | 2024-04-10T01:26:50Z |
| format | Article |
| id | doaj.art-1afaedbb3e684f898634dcf9133f7e22 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:26:50Z |
| publishDate | 2021-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-1afaedbb3e684f898634dcf9133f7e222023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102021-02-01171576810.15360/1813-9779-2021-1-57-681779Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain InjuryG. A. Boyarinov0O. D. Solovyova1E. I. Yakovleva2L V. Boyarinova3A. V. Deryugina4Приволжский исследовательский медицинский университетПриволжский исследовательский медицинский университетПриволжский исследовательский медицинский университетПриволжский исследовательский медицинский университетНациональный исследовательский Нижегородский государственный университет им. Н. И. ЛобачевскогоThe aim of the study was to investigate the effect of ethylmethylhydroxypyridine on the ultrastructural alterations in endothelial cells of liver sinusoidal capillaries (SC) and primary hemostasis in the acute phase of traumatic brain injury (TBI).Materials and methods. Ultrastructural endothelial cell changes were studied in 36 female outbred rats in the acute phase of TBI using electron microscopy, and the platelet count was determined using a blood analyzer. The experimental group (n=18) animals received intraperitoneal injections of ethylmethylhydroxypyridine at the dose of 8.0 mg/kg per day for 12 days, and the control group (n=18) rats were administered with normal saline solution at the same dose.Results. Administration of ethylmethylhydroxypyridine in the early post TBI period reduced microvilli damage in endothelial, hepatic and stellate cells in the Disse space, whereas in the control group a significant decrease of these cells counts was detected. In contrast to the control group, the experimental group animals did not demonstrate thrombocytopenia on the days 1, 3, and 7 after injury. There was a significant increase in the platelet count compared with the baseline values, which was highest on day 12 after injury.Conclusion. Intraperitoneal administration of ethylmethylhydroxypyridine in rats in early post TBI period inhibited the TBI-associated damaging effect of secondary factors on liver sinusoid endothelial cells and platelet consumption.https://www.reanimatology.com/rmt/article/view/2014черепно-мозговая травмаэндотелийсинусоидные капилляры печенитромбоцитыэтилметилгидроксипиридинмексикор |
| spellingShingle | G. A. Boyarinov O. D. Solovyova E. I. Yakovleva L V. Boyarinova A. V. Deryugina Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury Общая реаниматология черепно-мозговая травма эндотелий синусоидные капилляры печени тромбоциты этилметилгидроксипиридин мексикор |
| title | Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury |
| title_full | Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury |
| title_fullStr | Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury |
| title_full_unstemmed | Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury |
| title_short | Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury |
| title_sort | metabolic correction of primary hemostasis in the acute phase of traumatic brain injury |
| topic | черепно-мозговая травма эндотелий синусоидные капилляры печени тромбоциты этилметилгидроксипиридин мексикор |
| url | https://www.reanimatology.com/rmt/article/view/2014 |
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