The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life. However, almost nothing is known about how AC activity is regulated through protein degradation mediated by ubiquitination or other mechanisms....

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Bibliographic Details
Main Authors: Wenbao Hu, Xiaojie Yu, Zhengzhao Liu, Ying Sun, Xibing Chen, Xin Yang, Xiaofen Li, Wai Kwan Lam, Yuanyuan Duan, Xu Cao, Hermann Steller, Kai Liu, Pingbo Huang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
cAMP
adenylyl cyclase
ubiquitination
TRIP-Br1
XIAP
degradation
Online Access:https://elifesciences.org/articles/28021

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