Preliminary in-silico analysis of vascular graft implantation configuration and surface modification
Abstract Vascular grafts are used to reconstruct congenital cardiac anomalies, redirect flow, and offer vascular access. Donor tissue, synthetic, or more recently tissue-engineered vascular grafts each carry limitations spanning compatibility, availability, durability and cost. Synthetic and tissue-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42998-y |
| _version_ | 1797576950695329792 |
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| author | Ray Prather Yashar Pourmoghadam Joseph Fadhli Faris Al-Mousily Kamal Pourmoghadam |
| author_facet | Ray Prather Yashar Pourmoghadam Joseph Fadhli Faris Al-Mousily Kamal Pourmoghadam |
| author_sort | Ray Prather |
| collection | DOAJ |
| description | Abstract Vascular grafts are used to reconstruct congenital cardiac anomalies, redirect flow, and offer vascular access. Donor tissue, synthetic, or more recently tissue-engineered vascular grafts each carry limitations spanning compatibility, availability, durability and cost. Synthetic and tissue-engineered grafts offer the advantage of design optimization using in-silico or in-vitro modeling techniques. We focus on an in-silico parametric study to evaluate implantation configuration alternatives and surface finishing impact of a novel silicon-lined vascular graft. The model consists of a synthetic 3D-generic model of a graft connecting the internal carotid artery to the jugular vein. The flow is assumed unsteady, incompressible, and blood is modeled as a non-Newtonian fluid. A comparison of detached eddy turbulence and laminar modeling to determine the required accuracy needed found mild differences mainly dictated by the roughness level. The conduit walls are modeled as non-compliant and fixed. The shunt configurations considered, are straight and curved with varied surface roughness. Following a grid convergence study, two shunt configurations are analyzed to better understand flow distribution, peak shear locations, stagnation regions and eddy formation. The curved shunt was found to have lower peak and mean wall-shear stress, while resulting in lower flow power system and decreased power loss across the graft. The curved smooth surface shunt shows lower peak and mean wall-shear stress and lower power loss when compared to the straight shunt. |
| first_indexed | 2024-03-10T22:01:05Z |
| format | Article |
| id | doaj.art-1afcab16a63b49f78a2940a7e900d88f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T22:01:05Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1afcab16a63b49f78a2940a7e900d88f2023-11-19T12:56:47ZengNature PortfolioScientific Reports2045-23222023-10-0113111010.1038/s41598-023-42998-yPreliminary in-silico analysis of vascular graft implantation configuration and surface modificationRay Prather0Yashar Pourmoghadam1Joseph Fadhli2Faris Al-Mousily3Kamal Pourmoghadam4Department of Biomedical Sciences, University of Central FloridaDepartment of Molecular and Cell Biology, University of California BerkeleyDepartment of Biomedical Sciences, University of Central FloridaDepartment of Medicine, College of Medicine, University of Central FloridaDepartment of Surgery, College of Medicine, University of Central FloridaAbstract Vascular grafts are used to reconstruct congenital cardiac anomalies, redirect flow, and offer vascular access. Donor tissue, synthetic, or more recently tissue-engineered vascular grafts each carry limitations spanning compatibility, availability, durability and cost. Synthetic and tissue-engineered grafts offer the advantage of design optimization using in-silico or in-vitro modeling techniques. We focus on an in-silico parametric study to evaluate implantation configuration alternatives and surface finishing impact of a novel silicon-lined vascular graft. The model consists of a synthetic 3D-generic model of a graft connecting the internal carotid artery to the jugular vein. The flow is assumed unsteady, incompressible, and blood is modeled as a non-Newtonian fluid. A comparison of detached eddy turbulence and laminar modeling to determine the required accuracy needed found mild differences mainly dictated by the roughness level. The conduit walls are modeled as non-compliant and fixed. The shunt configurations considered, are straight and curved with varied surface roughness. Following a grid convergence study, two shunt configurations are analyzed to better understand flow distribution, peak shear locations, stagnation regions and eddy formation. The curved shunt was found to have lower peak and mean wall-shear stress, while resulting in lower flow power system and decreased power loss across the graft. The curved smooth surface shunt shows lower peak and mean wall-shear stress and lower power loss when compared to the straight shunt.https://doi.org/10.1038/s41598-023-42998-y |
| spellingShingle | Ray Prather Yashar Pourmoghadam Joseph Fadhli Faris Al-Mousily Kamal Pourmoghadam Preliminary in-silico analysis of vascular graft implantation configuration and surface modification Scientific Reports |
| title | Preliminary in-silico analysis of vascular graft implantation configuration and surface modification |
| title_full | Preliminary in-silico analysis of vascular graft implantation configuration and surface modification |
| title_fullStr | Preliminary in-silico analysis of vascular graft implantation configuration and surface modification |
| title_full_unstemmed | Preliminary in-silico analysis of vascular graft implantation configuration and surface modification |
| title_short | Preliminary in-silico analysis of vascular graft implantation configuration and surface modification |
| title_sort | preliminary in silico analysis of vascular graft implantation configuration and surface modification |
| url | https://doi.org/10.1038/s41598-023-42998-y |
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