Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa
Cyanobacterial blooms are serious environmental issues in global freshwater ecosystems. Nitrogen limitation is one of the most important strategies to control cyanobacterial blooms. However, recent researches showed that N limitation does not effectively control the bloom; oppositely, N limitation i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.511801/full |
| _version_ | 1818532279605002240 |
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| author | Hui Jin Hui Jin Yong Min Lao Ke Zhen Ying Jin Zhou Zhong Hua Cai |
| author_facet | Hui Jin Hui Jin Yong Min Lao Ke Zhen Ying Jin Zhou Zhong Hua Cai |
| author_sort | Hui Jin |
| collection | DOAJ |
| description | Cyanobacterial blooms are serious environmental issues in global freshwater ecosystems. Nitrogen limitation is one of the most important strategies to control cyanobacterial blooms. However, recent researches showed that N limitation does not effectively control the bloom; oppositely, N limitation induces N-fixing cyanobacterial blooms. The mechanism underlying this ecological event is elusive. In this study, we found that N limitation enhances stress tolerance of Microcystis aeruginosa by triggering stringent response (SR), one of the most important bacterial adaptive responses to environmental stresses. Initiation of SR exerted protective effects on the cells against salt and oxidative stresses by promoting colony formation, maintaining membrane integrity, increasing photosynthetic performance, reducing ROS production, upregulating stress-related genes, etc. These protections possibly help M. aeruginosa maintain their population number during seasonal N limitation. As SR has been proven to be involved in nitrogen fixing under N limitation conditions, the potential role of SR in driving the shift and succession of cyanobacterial blooms was discussed. Our findings provide cellular evidence and possible mechanisms that reducing N input is ineffective for bloom control. |
| first_indexed | 2024-12-11T17:43:25Z |
| format | Article |
| id | doaj.art-1afd1b80604646928f72796f2dba124c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T17:43:25Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1afd1b80604646928f72796f2dba124c2022-12-22T00:56:27ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-11-011110.3389/fmicb.2020.511801511801Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosaHui Jin0Hui Jin1Yong Min Lao2Ke Zhen Ying3Jin Zhou4Zhong Hua Cai5Shenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen, ChinaShenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaShenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaShenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaCyanobacterial blooms are serious environmental issues in global freshwater ecosystems. Nitrogen limitation is one of the most important strategies to control cyanobacterial blooms. However, recent researches showed that N limitation does not effectively control the bloom; oppositely, N limitation induces N-fixing cyanobacterial blooms. The mechanism underlying this ecological event is elusive. In this study, we found that N limitation enhances stress tolerance of Microcystis aeruginosa by triggering stringent response (SR), one of the most important bacterial adaptive responses to environmental stresses. Initiation of SR exerted protective effects on the cells against salt and oxidative stresses by promoting colony formation, maintaining membrane integrity, increasing photosynthetic performance, reducing ROS production, upregulating stress-related genes, etc. These protections possibly help M. aeruginosa maintain their population number during seasonal N limitation. As SR has been proven to be involved in nitrogen fixing under N limitation conditions, the potential role of SR in driving the shift and succession of cyanobacterial blooms was discussed. Our findings provide cellular evidence and possible mechanisms that reducing N input is ineffective for bloom control.https://www.frontiersin.org/articles/10.3389/fmicb.2020.511801/fullstringent responsestress toleranceMicrocystis aeruginosacyanobacterial bloomsguanosine 3′,5′-bisdiphosphate |
| spellingShingle | Hui Jin Hui Jin Yong Min Lao Ke Zhen Ying Jin Zhou Zhong Hua Cai Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa Frontiers in Microbiology stringent response stress tolerance Microcystis aeruginosa cyanobacterial blooms guanosine 3′,5′-bisdiphosphate |
| title | Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa |
| title_full | Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa |
| title_fullStr | Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa |
| title_full_unstemmed | Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa |
| title_short | Stringent Response Regulates Stress Resistance in Cyanobacterium Microcystis aeruginosa |
| title_sort | stringent response regulates stress resistance in cyanobacterium microcystis aeruginosa |
| topic | stringent response stress tolerance Microcystis aeruginosa cyanobacterial blooms guanosine 3′,5′-bisdiphosphate |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.511801/full |
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