Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling

Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling

Abstract Background Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the role it plays in AMD remains unclear. Herein, we investigated the anti...

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Bibliographic Details
Main Authors: Kai Wang, Yong-Syuan Chen, Hsiang-Wen Chien, Hui-Ling Chiou, Shun-Fa Yang, Yi-Hsien Hsieh
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cell & Bioscience
Subjects:
Melatonin
Retinal pigment epithelial cells
BNIP3
HIF-1α
LC3B
Mitophagy
Online Access:https://doi.org/10.1186/s13578-022-00879-3

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