A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid)
The cationic platinum(II) organometallic complex [Pt(terpy)Me]<sup>+</sup> (terpy = 2,2′:6′,2″-terpyridine) at mild acidic pH interacts with poly(L-glutamic acid) (L-PGA) in its α-helix conformation, affording chiral supramolecular adducts. Their kinetics of formation have been investiga...
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1176 |
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| author | Maria Angela Castriciano Roberto Zagami Antonino Mazzaglia Andrea Romeo Luigi Monsù Scolaro |
| author_facet | Maria Angela Castriciano Roberto Zagami Antonino Mazzaglia Andrea Romeo Luigi Monsù Scolaro |
| author_sort | Maria Angela Castriciano |
| collection | DOAJ |
| description | The cationic platinum(II) organometallic complex [Pt(terpy)Me]<sup>+</sup> (terpy = 2,2′:6′,2″-terpyridine) at mild acidic pH interacts with poly(L-glutamic acid) (L-PGA) in its α-helix conformation, affording chiral supramolecular adducts. Their kinetics of formation have been investigated in detail as a function of the concentrations of both reagents and changing pH, ionic strength, the length of the polymeric scaffold and temperature. After a very fast early stage, the kinetic traces have been analyzed as three consecutive steps, suggesting a mechanism based on the electrostatic fast formation of a not-organized aggregate that subsequently evolves through different rearrangements to form the eventual supramolecular adduct. A model for this species has been proposed based on (i) the attractive electrostatic interaction of the cationic platinum(II) complexes and the polyelectrolyte and (ii) the π-stacking interactions acting among the [Pt(terpy)Me]<sup>+</sup> units. |
| first_indexed | 2024-03-08T09:52:33Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:52:33Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1afed04afe2d4cb48d80dea4452231252024-01-29T13:57:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252117610.3390/ijms25021176A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid)Maria Angela Castriciano0Roberto Zagami1Antonino Mazzaglia2Andrea Romeo3Luigi Monsù Scolaro4Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, V.le F. Stagno D’Alcontres, 31, 98166 Messina, ItalyDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, V.le F. Stagno D’Alcontres, 31, 98166 Messina, ItalyCNR-ISMN Istituto per lo Studio dei Materiali Nanostrutturati c/o Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, V.le F. Stagno D’Alcontres, 31, 98166 Messina, ItalyDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, V.le F. Stagno D’Alcontres, 31, 98166 Messina, ItalyDipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, V.le F. Stagno D’Alcontres, 31, 98166 Messina, ItalyThe cationic platinum(II) organometallic complex [Pt(terpy)Me]<sup>+</sup> (terpy = 2,2′:6′,2″-terpyridine) at mild acidic pH interacts with poly(L-glutamic acid) (L-PGA) in its α-helix conformation, affording chiral supramolecular adducts. Their kinetics of formation have been investigated in detail as a function of the concentrations of both reagents and changing pH, ionic strength, the length of the polymeric scaffold and temperature. After a very fast early stage, the kinetic traces have been analyzed as three consecutive steps, suggesting a mechanism based on the electrostatic fast formation of a not-organized aggregate that subsequently evolves through different rearrangements to form the eventual supramolecular adduct. A model for this species has been proposed based on (i) the attractive electrostatic interaction of the cationic platinum(II) complexes and the polyelectrolyte and (ii) the π-stacking interactions acting among the [Pt(terpy)Me]<sup>+</sup> units.https://www.mdpi.com/1422-0067/25/2/1176platinum(II) complexessupramolecular adductschiralitykinetics of aggregation |
| spellingShingle | Maria Angela Castriciano Roberto Zagami Antonino Mazzaglia Andrea Romeo Luigi Monsù Scolaro A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) International Journal of Molecular Sciences platinum(II) complexes supramolecular adducts chirality kinetics of aggregation |
| title | A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) |
| title_full | A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) |
| title_fullStr | A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) |
| title_full_unstemmed | A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) |
| title_short | A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2″-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid) |
| title_sort | kinetic investigation of the supramolecular chiral self assembling process of cationic organometallic 2 2 6 2 terpyridine methylplatinum ii complexes with poly l glutamic acid |
| topic | platinum(II) complexes supramolecular adducts chirality kinetics of aggregation |
| url | https://www.mdpi.com/1422-0067/25/2/1176 |
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