Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial
The effects of fish oil supplementation for nine weeks on quality of life, body weight and muscle mass change in gastrointestinal cancer patients during chemotherapy was investigated. Forty-five patients with colorectal or gastric cancer initiating chemotherapy treatment were studied in a triple-bli...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617300531 |
| _version_ | 1819292841422094336 |
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| author | Michel Carlos Mocellin Carolina de Quadros Camargo Maria Emilia de Souza Fabre Erasmo Benicio Santos de Moraes Trindade |
| author_facet | Michel Carlos Mocellin Carolina de Quadros Camargo Maria Emilia de Souza Fabre Erasmo Benicio Santos de Moraes Trindade |
| author_sort | Michel Carlos Mocellin |
| collection | DOAJ |
| description | The effects of fish oil supplementation for nine weeks on quality of life, body weight and muscle mass change in gastrointestinal cancer patients during chemotherapy was investigated. Forty-five patients with colorectal or gastric cancer initiating chemotherapy treatment were studied in a triple-blind, placebo controlled trial. Patients were randomly assigned to receive 3.6 g/day of fish oil (1.55 g EPA + DHA; n = 22) or placebo (n = 23). Body weight, body composition and quality of life were assessed at baseline and at week 9. Pooled analysis did not show statistical significance between the two groups for weight and free-fat mass change. However, subgroup analyses demonstrated that fish oil prevented loss of muscle mass. Patients that took fish oil had lower scores for nausea/vomiting and appetite loss after the first nine weeks of chemotherapy, but had higher constipation scores. Thus, the results indicate that certain groups of patients with gastrointestinal cancer may benefit from fish oil intake concomitant with chemotherapy. |
| first_indexed | 2024-12-24T04:00:56Z |
| format | Article |
| id | doaj.art-1b00149ecd484f1f986eb8a58e5166ca |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:00:56Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1b00149ecd484f1f986eb8a58e5166ca2022-12-21T17:16:18ZengElsevierJournal of Functional Foods1756-46462017-04-0131113122Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trialMichel Carlos Mocellin0Carolina de Quadros Camargo1Maria Emilia de Souza Fabre2Erasmo Benicio Santos de Moraes Trindade3Federal University of Santa Catarina, Nutrition Department, Graduate Program of Nutrition, Florianópolis, Santa Catarina, Brazil; Corresponding author at: Graduate Program of Nutrition, Nutrition Department, Health Sciences Center, University Campus - Trindade, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil.Federal University of Santa Catarina, Nutrition Department, Graduate Program of Nutrition, Florianópolis, Santa Catarina, BrazilOncology Research Center of Santa Catarina – CEPON/SC, Ambulatory of Nutrition Assistance, Florianópolis, Santa Catarina, BrazilFederal University of Santa Catarina, Nutrition Department, Graduate Program of Nutrition, Florianópolis, Santa Catarina, BrazilThe effects of fish oil supplementation for nine weeks on quality of life, body weight and muscle mass change in gastrointestinal cancer patients during chemotherapy was investigated. Forty-five patients with colorectal or gastric cancer initiating chemotherapy treatment were studied in a triple-blind, placebo controlled trial. Patients were randomly assigned to receive 3.6 g/day of fish oil (1.55 g EPA + DHA; n = 22) or placebo (n = 23). Body weight, body composition and quality of life were assessed at baseline and at week 9. Pooled analysis did not show statistical significance between the two groups for weight and free-fat mass change. However, subgroup analyses demonstrated that fish oil prevented loss of muscle mass. Patients that took fish oil had lower scores for nausea/vomiting and appetite loss after the first nine weeks of chemotherapy, but had higher constipation scores. Thus, the results indicate that certain groups of patients with gastrointestinal cancer may benefit from fish oil intake concomitant with chemotherapy.http://www.sciencedirect.com/science/article/pii/S1756464617300531Fish oilChemotherapyQuality of lifeBody compositionn-3 polyunsaturated fatty acidsGastrointestinal cancer |
| spellingShingle | Michel Carlos Mocellin Carolina de Quadros Camargo Maria Emilia de Souza Fabre Erasmo Benicio Santos de Moraes Trindade Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial Journal of Functional Foods Fish oil Chemotherapy Quality of life Body composition n-3 polyunsaturated fatty acids Gastrointestinal cancer |
| title | Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial |
| title_full | Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial |
| title_fullStr | Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial |
| title_full_unstemmed | Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial |
| title_short | Fish oil effects on quality of life, body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy: A triple blind, randomized clinical trial |
| title_sort | fish oil effects on quality of life body weight and free fat mass change in gastrointestinal cancer patients undergoing chemotherapy a triple blind randomized clinical trial |
| topic | Fish oil Chemotherapy Quality of life Body composition n-3 polyunsaturated fatty acids Gastrointestinal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617300531 |
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