Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study
ObjectiveThe aim of this study was to investigate the relationship between blood pressure variability (BPV) and poststroke cognitive impairment (PSCI).MethodsSeven-hundred ninety-six patients with acute ischemic stroke were included in this study. Midterm BPV was evaluated by calculating the SD and...
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00365/full |
| _version_ | 1818557540604051456 |
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| author | Shan Geng Na Liu Pin Meng Niu Ji Yong’an Sun Yingda Xu Guanghui Zhang Xiaobing He Zenglin Cai Bei Wang Bei Xu Zaipo Li Xiaoqin Niu Yongjin Zhang Bingchao Xu Xinyu Zhou Mingli He |
| author_facet | Shan Geng Na Liu Pin Meng Niu Ji Yong’an Sun Yingda Xu Guanghui Zhang Xiaobing He Zenglin Cai Bei Wang Bei Xu Zaipo Li Xiaoqin Niu Yongjin Zhang Bingchao Xu Xinyu Zhou Mingli He |
| author_sort | Shan Geng |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to investigate the relationship between blood pressure variability (BPV) and poststroke cognitive impairment (PSCI).MethodsSeven-hundred ninety-six patients with acute ischemic stroke were included in this study. Midterm BPV was evaluated by calculating the SD and coefficient of variation (CV, 100 × SD/mean) of systolic blood pressure (SBP) and diastolic blood pressure during the 7 days after stroke onset. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) at admission and at all follow-up visits. Patients with MoCA scores <26 were considered to have PSCI.ResultsThe incidence of PSCI reached its peak (72%) 3 months after stroke onset and decreased to 30.3% at 12 months poststroke. After adjusting for covariables, the increase in the prevalence of PSCI at 3 months was independently associated with increases in the CV of blood pressure during the 7 days after stroke [odds ratios and 95% CI for patients in the second to fifth quintiles of SBP CV were 2.28 (1.18, 4.39), 2.33 (1.18, 4.62), 2.69 (1.31, 5.53), and 4.76 (1.95, 11.67), respectively]. Sub-analysis of the MoCA scores revealed that the patients had impairments in visuoperceptual abilities and executive functions, as well as in naming and delayed recall (p < 0.05).ConclusionMidterm BPV during the early phase of acute ischemic stroke is independently associated with PSCI, especially in the visuoperceptual, executive, and delayed recall domains.Clinical Trial Registrationhttp://www.chictr.org.cn, identifier ChiCTR-TRC-14004804. |
| first_indexed | 2024-12-14T00:00:51Z |
| format | Article |
| id | doaj.art-1b02449bceb84538826f082331603744 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T00:00:51Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1b02449bceb84538826f0823316037442022-12-21T23:26:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-07-01810.3389/fneur.2017.00365274513Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort StudyShan Geng0Na Liu1Pin Meng2Niu Ji3Yong’an Sun4Yingda Xu5Guanghui Zhang6Xiaobing He7Zenglin Cai8Bei Wang9Bei Xu10Zaipo Li11Xiaoqin Niu12Yongjin Zhang13Bingchao Xu14Xinyu Zhou15Mingli He16Department of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Neurology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaObjectiveThe aim of this study was to investigate the relationship between blood pressure variability (BPV) and poststroke cognitive impairment (PSCI).MethodsSeven-hundred ninety-six patients with acute ischemic stroke were included in this study. Midterm BPV was evaluated by calculating the SD and coefficient of variation (CV, 100 × SD/mean) of systolic blood pressure (SBP) and diastolic blood pressure during the 7 days after stroke onset. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) at admission and at all follow-up visits. Patients with MoCA scores <26 were considered to have PSCI.ResultsThe incidence of PSCI reached its peak (72%) 3 months after stroke onset and decreased to 30.3% at 12 months poststroke. After adjusting for covariables, the increase in the prevalence of PSCI at 3 months was independently associated with increases in the CV of blood pressure during the 7 days after stroke [odds ratios and 95% CI for patients in the second to fifth quintiles of SBP CV were 2.28 (1.18, 4.39), 2.33 (1.18, 4.62), 2.69 (1.31, 5.53), and 4.76 (1.95, 11.67), respectively]. Sub-analysis of the MoCA scores revealed that the patients had impairments in visuoperceptual abilities and executive functions, as well as in naming and delayed recall (p < 0.05).ConclusionMidterm BPV during the early phase of acute ischemic stroke is independently associated with PSCI, especially in the visuoperceptual, executive, and delayed recall domains.Clinical Trial Registrationhttp://www.chictr.org.cn, identifier ChiCTR-TRC-14004804.http://journal.frontiersin.org/article/10.3389/fneur.2017.00365/fullstrokecognitive impairmentMontreal Cognitive Assessmentblood pressure variabilitysubfactors |
| spellingShingle | Shan Geng Na Liu Pin Meng Niu Ji Yong’an Sun Yingda Xu Guanghui Zhang Xiaobing He Zenglin Cai Bei Wang Bei Xu Zaipo Li Xiaoqin Niu Yongjin Zhang Bingchao Xu Xinyu Zhou Mingli He Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study Frontiers in Neurology stroke cognitive impairment Montreal Cognitive Assessment blood pressure variability subfactors |
| title | Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study |
| title_full | Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study |
| title_fullStr | Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study |
| title_full_unstemmed | Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study |
| title_short | Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study |
| title_sort | midterm blood pressure variability is associated with poststroke cognitive impairment a prospective cohort study |
| topic | stroke cognitive impairment Montreal Cognitive Assessment blood pressure variability subfactors |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00365/full |
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