Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial
Introduction: Pegylated Interferon Alpha (Peg-IFN) in combination with other drugs is the standard treatment for chronic hepatitis C infection (HCV) and is related to severe painful symptoms. The aim of this study was access the efficacy of transcranial direct current stimulation (tDCS) in controlli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00498/full |
| _version_ | 1819058669756612608 |
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| author | Aline Patricia Brietzke Joanna Ripoll Rozisky Jairo Alberto Dussan-Sarria Alícia eDeitos Gabriela eLaste Priscila Fortes Thomas Hoppe Suzana eMuller Iraci Lucena da Silva Torres Mario Reis Alvares-da-Silva Rivadavio eAmorim Felipe eFregni WOLNEI eCAUMO |
| author_facet | Aline Patricia Brietzke Joanna Ripoll Rozisky Jairo Alberto Dussan-Sarria Alícia eDeitos Gabriela eLaste Priscila Fortes Thomas Hoppe Suzana eMuller Iraci Lucena da Silva Torres Mario Reis Alvares-da-Silva Rivadavio eAmorim Felipe eFregni WOLNEI eCAUMO |
| author_sort | Aline Patricia Brietzke |
| collection | DOAJ |
| description | Introduction: Pegylated Interferon Alpha (Peg-IFN) in combination with other drugs is the standard treatment for chronic hepatitis C infection (HCV) and is related to severe painful symptoms. The aim of this study was access the efficacy of transcranial direct current stimulation (tDCS) in controlling the painful symptoms related to Peg-IFN side effects. Material and Methods: In this phase II double-blind trial, twenty eight (n=28) HCV subjects were randomized to receive either five consecutive days of active tDCS (n=14) or sham (n=14) during five consecutive days with anodal stimulation over the primary motor cortex region using 2 mA for 20 minutes. The primary outcomes were visual analogue scale (VAS) pain and brain-derived neurotrophic factor (BDNF) serum levels. Secondary outcomes were the pressure-pain threshold (PPT), the Brazilian Profile of Chronic Pain: Screen (B-PCP:S) and drug analgesics use. Results: tDCS reduced the VAS scores (P<0.003), with a mean pain drop of 56% (p<0.001). Furthermore, tDCS was able to enhance BDNF levels (p<0.01). The mean increase was 37.48% in the active group. Finally, tDCS raised PPT (p<0.001) and reduced the B-PCP:S scores and analgesic use (p<0.05). Conclusions: Five sessions of tDCS were effective in reducing the painful symptoms in HCV patients undergoing Peg-IFN treatment. These findings support the efficacy of tDCS as a promising therapeutic tool to improve the tolerance of the side effects related to the use of Peg-IFN. Future larger studies (phase III and IV trials) are needed to confirm the clinical use of the therapeutic effects of tDCS in such condition. Trial registration: Brazilian Human Health Regulator for Research with the approval number CAAE 07802012.0.0000.5327 |
| first_indexed | 2024-12-21T13:58:53Z |
| format | Article |
| id | doaj.art-1b02e45ccf3349b68b84d6d0211e517c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T13:58:53Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-1b02e45ccf3349b68b84d6d0211e517c2022-12-21T19:01:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-01-01910.3389/fnins.2015.00498173390Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trialAline Patricia Brietzke0Joanna Ripoll Rozisky1Jairo Alberto Dussan-Sarria2Alícia eDeitos3Gabriela eLaste4Priscila Fortes Thomas Hoppe5Suzana eMuller6Iraci Lucena da Silva Torres7Mario Reis Alvares-da-Silva8Rivadavio eAmorim9Felipe eFregni10WOLNEI eCAUMO11Universidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulPost-Doctoral Research FellowPost-Doctoral Research FellowUniversidade Federal do Rio Grande do SulIntroduction: Pegylated Interferon Alpha (Peg-IFN) in combination with other drugs is the standard treatment for chronic hepatitis C infection (HCV) and is related to severe painful symptoms. The aim of this study was access the efficacy of transcranial direct current stimulation (tDCS) in controlling the painful symptoms related to Peg-IFN side effects. Material and Methods: In this phase II double-blind trial, twenty eight (n=28) HCV subjects were randomized to receive either five consecutive days of active tDCS (n=14) or sham (n=14) during five consecutive days with anodal stimulation over the primary motor cortex region using 2 mA for 20 minutes. The primary outcomes were visual analogue scale (VAS) pain and brain-derived neurotrophic factor (BDNF) serum levels. Secondary outcomes were the pressure-pain threshold (PPT), the Brazilian Profile of Chronic Pain: Screen (B-PCP:S) and drug analgesics use. Results: tDCS reduced the VAS scores (P<0.003), with a mean pain drop of 56% (p<0.001). Furthermore, tDCS was able to enhance BDNF levels (p<0.01). The mean increase was 37.48% in the active group. Finally, tDCS raised PPT (p<0.001) and reduced the B-PCP:S scores and analgesic use (p<0.05). Conclusions: Five sessions of tDCS were effective in reducing the painful symptoms in HCV patients undergoing Peg-IFN treatment. These findings support the efficacy of tDCS as a promising therapeutic tool to improve the tolerance of the side effects related to the use of Peg-IFN. Future larger studies (phase III and IV trials) are needed to confirm the clinical use of the therapeutic effects of tDCS in such condition. Trial registration: Brazilian Human Health Regulator for Research with the approval number CAAE 07802012.0.0000.5327http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00498/fullChronic PainHepatitis Ctranscranial direct current stimulationHepatitis C virusPEG-INF |
| spellingShingle | Aline Patricia Brietzke Joanna Ripoll Rozisky Jairo Alberto Dussan-Sarria Alícia eDeitos Gabriela eLaste Priscila Fortes Thomas Hoppe Suzana eMuller Iraci Lucena da Silva Torres Mario Reis Alvares-da-Silva Rivadavio eAmorim Felipe eFregni WOLNEI eCAUMO Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial Frontiers in Neuroscience Chronic Pain Hepatitis C transcranial direct current stimulation Hepatitis C virus PEG-INF |
| title | Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial |
| title_full | Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial |
| title_fullStr | Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial |
| title_full_unstemmed | Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial |
| title_short | Neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic Hepatitis C: a phase II randomized, double blind, sham controlled trial |
| title_sort | neuroplastic effects of transcranial direct current stimulation on painful symptoms reduction in chronic hepatitis c a phase ii randomized double blind sham controlled trial |
| topic | Chronic Pain Hepatitis C transcranial direct current stimulation Hepatitis C virus PEG-INF |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00498/full |
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