| Summary: | <p><b>Background:</b> Recurrent thoracotomies regardless of the cause are not a rare occurrence. However, each thoracotomy results in adhesion to some extent. This adhesions increase morbidity and mortality presents a significant inconvenience for surgeons and prolongs the length of operations.</p><p><b>Objective: </b>We investigated the efficacy of Prevadh®, an anti-adhesion agent to prevent intrapleural adesions following thoracotomy in a rat model.</p><p><b>Methods:</b> Twenty male adult Wistar Albino rats were divided into a sham group (Group A, <i>n</i> = 4), a control group (Group B, <i>n</i> = 8), and a study group (Group C, <i>n</i> = 8). Only left thoracotomy was performed in Group A. Group B underwent left thoracotomy, induction of adhesion, and 1 ml saline solution was administered to the thoracic cavity. However, in Group C underwent left thoracotomy, induction of adhesion, and Prevadh® was placed between the pleura and the lung. The rats were sacrificed on day 21, and adhesions were analyzed using both macroscopic and histopathological methods. The results were statistically analyzed. A value of <i>P</i><0.05 was considered statistically significant.</p><p><b>Results: </b>Mean lengths of adhesion differed statistically significantly among all three groups, while mean intensity of adhesion differed between Group A and Group B, and between Group B and Group C (<i>P</i>>0.05). There was also a statistically significant difference between Group A and Group C in mesothelium proliferation score (<i>P</i>>0.05). No statistically significant differences were found among the groups in terms of pleural thickness, macrophage and mononuclear cell infiltration (<i>P</i>>0.05).</p><p><b>Conclusions: </b>Prevadh® was shown in a rat model to effectively prevent post-thoracotomy adhesions.</p>
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