Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia
Sivakumar Balasubramanian,1 Aswathy Ravindran Girija,1 Yutaka Nagaoka,1 Seiki Iwai,1 Masashi Suzuki,1 Venugopal Kizhikkilot,2 Yasuhiko Yoshida,1 Toru Maekawa,1 Sakthikumar Dasappan Nair1 1Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe...
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Format: | Article |
Language: | English |
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Dove Medical Press
2014-01-01
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Series: | International Journal of Nanomedicine |
Online Access: | http://www.dovepress.com/curcumin-and-5-fluorouracil-loaded-folate--and-transferrin-decorated-p-a15449 |
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author | Balasubramanian S Girija AR Nagaoka Y Iwai S Suzuki M, Kizhikkilot V Yoshida Y Maekawa T Nair SD |
author_facet | Balasubramanian S Girija AR Nagaoka Y Iwai S Suzuki M, Kizhikkilot V Yoshida Y Maekawa T Nair SD |
author_sort | Balasubramanian S |
collection | DOAJ |
description | Sivakumar Balasubramanian,1 Aswathy Ravindran Girija,1 Yutaka Nagaoka,1 Seiki Iwai,1 Masashi Suzuki,1 Venugopal Kizhikkilot,2 Yasuhiko Yoshida,1 Toru Maekawa,1 Sakthikumar Dasappan Nair1 1Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan; 2Department of Respiratory Medicine, Sooriya Hospital, Chennai, India Abstract: The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis. Keywords: nanotechnology, curcumin, 5FU, folate, transferrin, PLGA nanoparticle, magnetic hyperthermia |
first_indexed | 2024-12-24T03:57:39Z |
format | Article |
id | doaj.art-1b067eeea0e04bb4ac897d8a5a05272c |
institution | Directory Open Access Journal |
issn | 1178-2013 |
language | English |
last_indexed | 2024-12-24T03:57:39Z |
publishDate | 2014-01-01 |
publisher | Dove Medical Press |
record_format | Article |
series | International Journal of Nanomedicine |
spelling | doaj.art-1b067eeea0e04bb4ac897d8a5a05272c2022-12-21T17:16:24ZengDove Medical PressInternational Journal of Nanomedicine1178-20132014-01-012014Issue 143745915449Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermiaBalasubramanian SGirija ARNagaoka YIwai SSuzuki M, Kizhikkilot VYoshida YMaekawa TNair SDSivakumar Balasubramanian,1 Aswathy Ravindran Girija,1 Yutaka Nagaoka,1 Seiki Iwai,1 Masashi Suzuki,1 Venugopal Kizhikkilot,2 Yasuhiko Yoshida,1 Toru Maekawa,1 Sakthikumar Dasappan Nair1 1Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan; 2Department of Respiratory Medicine, Sooriya Hospital, Chennai, India Abstract: The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis. Keywords: nanotechnology, curcumin, 5FU, folate, transferrin, PLGA nanoparticle, magnetic hyperthermiahttp://www.dovepress.com/curcumin-and-5-fluorouracil-loaded-folate--and-transferrin-decorated-p-a15449 |
spellingShingle | Balasubramanian S Girija AR Nagaoka Y Iwai S Suzuki M, Kizhikkilot V Yoshida Y Maekawa T Nair SD Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia International Journal of Nanomedicine |
title | Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia |
title_full | Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia |
title_fullStr | Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia |
title_full_unstemmed | Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia |
title_short | Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia |
title_sort | curcumin and 5 fluorouracil loaded folate and transferrin decorated polymeric magnetic nanoformulation a synergistic cancer therapeutic approach accelerated by magnetic hyperthermia |
url | http://www.dovepress.com/curcumin-and-5-fluorouracil-loaded-folate--and-transferrin-decorated-p-a15449 |
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