Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer
Abstract Serum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) upt...
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-91608-2 |
| _version_ | 1818403261162455040 |
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| author | Jae-Hoon Lee Hye Sun Lee Soyoung Kim Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang |
| author_facet | Jae-Hoon Lee Hye Sun Lee Soyoung Kim Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang |
| author_sort | Jae-Hoon Lee |
| collection | DOAJ |
| description | Abstract Serum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) uptake in the bone marrow and spleen of patients with CRC and evaluate the relationship between FDG uptake estimates in these organs and serum inflammatory markers. In total, 411 patients who underwent preoperative FDG PET/computed tomography (CT) within 1 month of surgery were enrolled. The mean standardized uptake values of the bone marrow and spleen were normalized to the value of the liver, thereby generating bone marrow-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) estimates. The value of BLR and SLR in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between BLR or SLR and neutrophil-to-lymphocyte ratio (NLR) was evaluated. The predictive accuracy of BLR alone and in combination with SLR was compared using the integrated area under the receiver operating characteristic curves (iAUC). In the univariate analysis, BLR (> 1.06) and SLR (> 0.93) were significant predictors of OS. In the multivariate analysis, BLR was an independent predictor of OS (hazard ratio = 5.279; p < 0.001). Both BLR and SLR were correlated with NLR (p < 0.001). A combination of BLR and SLR was better than BLR alone at CRC prognostication (iAUC, 0.561 vs. 0.542). FDG uptake estimates in the bone marrow and spleen may be useful imaging-derived biomarkers of systemic inflammation, supporting CRC prognostication. |
| first_indexed | 2024-12-14T08:21:27Z |
| format | Article |
| id | doaj.art-1b0736e70ab84c8c8e88402846619cc4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:21:27Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1b0736e70ab84c8c8e88402846619cc42022-12-21T23:09:47ZengNature PortfolioScientific Reports2045-23222021-06-0111111010.1038/s41598-021-91608-2Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancerJae-Hoon Lee0Hye Sun Lee1Soyoung Kim2Eun Jung Park3Seung Hyuk Baik4Tae Joo Jeon5Kang Young Lee6Young Hoon Ryu7Jeonghyun Kang8Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineBiostatistics Collaboration Unit, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract Serum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) uptake in the bone marrow and spleen of patients with CRC and evaluate the relationship between FDG uptake estimates in these organs and serum inflammatory markers. In total, 411 patients who underwent preoperative FDG PET/computed tomography (CT) within 1 month of surgery were enrolled. The mean standardized uptake values of the bone marrow and spleen were normalized to the value of the liver, thereby generating bone marrow-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) estimates. The value of BLR and SLR in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between BLR or SLR and neutrophil-to-lymphocyte ratio (NLR) was evaluated. The predictive accuracy of BLR alone and in combination with SLR was compared using the integrated area under the receiver operating characteristic curves (iAUC). In the univariate analysis, BLR (> 1.06) and SLR (> 0.93) were significant predictors of OS. In the multivariate analysis, BLR was an independent predictor of OS (hazard ratio = 5.279; p < 0.001). Both BLR and SLR were correlated with NLR (p < 0.001). A combination of BLR and SLR was better than BLR alone at CRC prognostication (iAUC, 0.561 vs. 0.542). FDG uptake estimates in the bone marrow and spleen may be useful imaging-derived biomarkers of systemic inflammation, supporting CRC prognostication.https://doi.org/10.1038/s41598-021-91608-2 |
| spellingShingle | Jae-Hoon Lee Hye Sun Lee Soyoung Kim Eun Jung Park Seung Hyuk Baik Tae Joo Jeon Kang Young Lee Young Hoon Ryu Jeonghyun Kang Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer Scientific Reports |
| title | Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer |
| title_full | Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer |
| title_fullStr | Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer |
| title_full_unstemmed | Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer |
| title_short | Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer |
| title_sort | prognostic significance of bone marrow and spleen 18f fdg uptake in patients with colorectal cancer |
| url | https://doi.org/10.1038/s41598-021-91608-2 |
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