Processing and regulation of negative emotions in anorexia nervosa: An fMRI study
Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217303406 |
| _version_ | 1818010180752769024 |
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| author | Maria Seidel Joseph A. King Franziska Ritschel Ilka Boehm Daniel Geisler Fabio Bernardoni Matthias Beck Sophie Pauligk Ronald Biemann Alexander Strobel Thomas Goschke Henrik Walter Veit Roessner Stefan Ehrlich |
| author_facet | Maria Seidel Joseph A. King Franziska Ritschel Ilka Boehm Daniel Geisler Fabio Bernardoni Matthias Beck Sophie Pauligk Ronald Biemann Alexander Strobel Thomas Goschke Henrik Walter Veit Roessner Stefan Ehrlich |
| author_sort | Maria Seidel |
| collection | DOAJ |
| description | Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have been based largely on self-report data, and there is a relative lack of objective experimental evidence or neurobiological data.The current functional magnetic resonance imaging (fMRI) study investigated the hemodynamic correlates of passive viewing and voluntary downregulation of negative emotions by means of the reappraisal strategy detachment in AN patients. Detachment is regarded as adaptive regulation strategy associated with a reduction in emotion-related amygdala activity and increased recruitment of prefrontal brain regions associated with cognitive control processes. Emotion regulation efficacy was assessed via behavioral arousal ratings and fMRI activation elicited by an established experimental paradigm including negative images. Participants were instructed to either simply view emotional pictures or detach themselves from feelings triggered by the stimuli.The sample consisted of 36 predominantly adolescent female AN patients and a pairwise age-matched healthy control group. Behavioral and neuroimaging data analyses indicated a reduction of arousal and amygdala activity during the regulation condition for both patients and controls. However, compared with controls, individuals with AN showed increased activation in the amygdala as well as in the right dorsolateral prefrontal cortex (dlPFC) during the passive viewing of aversive compared with neutral pictures.These results extend previous findings indicative of altered processing of salient emotional stimuli in AN, but do not point to a general deficit in the voluntary regulation of negative emotions. Increased dlPFC activation in AN during passive viewing of negative stimuli is in line with the hypothesis that the disorder may be characterized by excessive self-control. Taken together, the data seem to suggest that reappraisal via detachment may be an effective strategy to reduce negative arousal for individuals with AN. Keywords: Emotion regulation, fMRI, Anorexia nervosa, Voluntary, Amygdala, dlPFC |
| first_indexed | 2024-04-14T05:52:00Z |
| format | Article |
| id | doaj.art-1b07fde7729541818dadb49d883fc3b9 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-14T05:52:00Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-1b07fde7729541818dadb49d883fc3b92022-12-22T02:09:05ZengElsevierNeuroImage: Clinical2213-15822018-01-011818Processing and regulation of negative emotions in anorexia nervosa: An fMRI studyMaria Seidel0Joseph A. King1Franziska Ritschel2Ilka Boehm3Daniel Geisler4Fabio Bernardoni5Matthias Beck6Sophie Pauligk7Ronald Biemann8Alexander Strobel9Thomas Goschke10Henrik Walter11Veit Roessner12Stefan Ehrlich13Division of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Translational Developmental Neuroscience Section, Eating Disorder Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyInstitute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Psychology, Technische Universität Dresden, Dresden, GermanyDepartment of Psychology, Technische Universität Dresden, Dresden, GermanyDepartment of Psychology, Charité Berlin, Berlin, GermanyTranslational Developmental Neuroscience Section, Eating Disorder Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Translational Developmental Neuroscience Section, Eating Disorder Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Corresponding author at: Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Dresden, Division of Psychological and Social Medicine and Developmental Neuroscience, Fetscherstraße 74, 01307 Dresden, Germany.Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have been based largely on self-report data, and there is a relative lack of objective experimental evidence or neurobiological data.The current functional magnetic resonance imaging (fMRI) study investigated the hemodynamic correlates of passive viewing and voluntary downregulation of negative emotions by means of the reappraisal strategy detachment in AN patients. Detachment is regarded as adaptive regulation strategy associated with a reduction in emotion-related amygdala activity and increased recruitment of prefrontal brain regions associated with cognitive control processes. Emotion regulation efficacy was assessed via behavioral arousal ratings and fMRI activation elicited by an established experimental paradigm including negative images. Participants were instructed to either simply view emotional pictures or detach themselves from feelings triggered by the stimuli.The sample consisted of 36 predominantly adolescent female AN patients and a pairwise age-matched healthy control group. Behavioral and neuroimaging data analyses indicated a reduction of arousal and amygdala activity during the regulation condition for both patients and controls. However, compared with controls, individuals with AN showed increased activation in the amygdala as well as in the right dorsolateral prefrontal cortex (dlPFC) during the passive viewing of aversive compared with neutral pictures.These results extend previous findings indicative of altered processing of salient emotional stimuli in AN, but do not point to a general deficit in the voluntary regulation of negative emotions. Increased dlPFC activation in AN during passive viewing of negative stimuli is in line with the hypothesis that the disorder may be characterized by excessive self-control. Taken together, the data seem to suggest that reappraisal via detachment may be an effective strategy to reduce negative arousal for individuals with AN. Keywords: Emotion regulation, fMRI, Anorexia nervosa, Voluntary, Amygdala, dlPFChttp://www.sciencedirect.com/science/article/pii/S2213158217303406 |
| spellingShingle | Maria Seidel Joseph A. King Franziska Ritschel Ilka Boehm Daniel Geisler Fabio Bernardoni Matthias Beck Sophie Pauligk Ronald Biemann Alexander Strobel Thomas Goschke Henrik Walter Veit Roessner Stefan Ehrlich Processing and regulation of negative emotions in anorexia nervosa: An fMRI study NeuroImage: Clinical |
| title | Processing and regulation of negative emotions in anorexia nervosa: An fMRI study |
| title_full | Processing and regulation of negative emotions in anorexia nervosa: An fMRI study |
| title_fullStr | Processing and regulation of negative emotions in anorexia nervosa: An fMRI study |
| title_full_unstemmed | Processing and regulation of negative emotions in anorexia nervosa: An fMRI study |
| title_short | Processing and regulation of negative emotions in anorexia nervosa: An fMRI study |
| title_sort | processing and regulation of negative emotions in anorexia nervosa an fmri study |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217303406 |
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