Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database
Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolep...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/1/43 |
| _version_ | 1797445248644808704 |
|---|---|
| author | Eva Feketeová Jozef Dragašek Katarína Klobučníková Peter Ďurdík Simona Čarnakovič Miriam Slavkovská Martina Chylová |
| author_facet | Eva Feketeová Jozef Dragašek Katarína Klobučníková Peter Ďurdík Simona Čarnakovič Miriam Slavkovská Martina Chylová |
| author_sort | Eva Feketeová |
| collection | DOAJ |
| description | Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical characteristics of these cases, and to look for narcoleptic and psychotic symptoms during re-evaluation years later. We identified three (4%) cases diagnosed with a psychotic episode in the course of NT1. They were diagnosed with NT1 by age ≤18 years. In the re-evaluation (mean follow-up 9.8 years), we identified one case with a dual diagnosis of NT1 and schizophrenia; two cases were diagnosed with a solitary psychotic episode in the course of NT1. NT1 patients diagnosed in the age ≤18 years are at higher risk of psychotic episode, and this may be related to higher vulnerability during the ongoing neurodevelopmental period. Comorbid schizophrenia with NT1 in the Slovakian Narcolepsy Database was within the prevalence expected in the general population. The solitary psychotic episode in the course of NT1 did not reduce the possibility of subsequent symptomatic treatment afterwards. |
| first_indexed | 2024-03-09T13:23:02Z |
| format | Article |
| id | doaj.art-1b08157143594b3f8a1f05df5e9c9c18 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T13:23:02Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1b08157143594b3f8a1f05df5e9c9c182023-11-30T21:26:47ZengMDPI AGBrain Sciences2076-34252022-12-011314310.3390/brainsci13010043Psychotic Episode and Schizophrenia in Slovakian Narcolepsy DatabaseEva Feketeová0Jozef Dragašek1Katarína Klobučníková2Peter Ďurdík3Simona Čarnakovič4Miriam Slavkovská5Martina Chylová6Department of Neurology, Faculty of Medicine, University of P.J. Šafárik and University Hospital of L. Pasteur, Trieda SNP 1, 04011 Košice, Slovakia1st Department of Psychiatry, Faculty of Medicine, University of P.J. Šafárik and University Hospital of L. Pasteur, Trieda SNP 1, 04011 Košice, Slovakia1st Department of Neurology, Faculty of Medicine, Comenius University and University Hospital in Bratislava, Mickiewiczova 13, 81369 Bratislava, SlovakiaClinic of Children and Adolescents, Jessenius Faculty of Medicine, Comenius University in Bratislava and University Hospital in Martin, Kollarova 2, 03659 Martin, Slovakia1st Department of Psychiatry, Faculty of Medicine, University of P.J. Šafárik and University Hospital of L. Pasteur, Trieda SNP 1, 04011 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, University of P.J. Šafárik and University Hospital of L. Pasteur, Trieda SNP 1, 04011 Košice, Slovakia1st Department of Psychiatry, Faculty of Medicine, University of P.J. Šafárik and University Hospital of L. Pasteur, Trieda SNP 1, 04011 Košice, SlovakiaNarcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical characteristics of these cases, and to look for narcoleptic and psychotic symptoms during re-evaluation years later. We identified three (4%) cases diagnosed with a psychotic episode in the course of NT1. They were diagnosed with NT1 by age ≤18 years. In the re-evaluation (mean follow-up 9.8 years), we identified one case with a dual diagnosis of NT1 and schizophrenia; two cases were diagnosed with a solitary psychotic episode in the course of NT1. NT1 patients diagnosed in the age ≤18 years are at higher risk of psychotic episode, and this may be related to higher vulnerability during the ongoing neurodevelopmental period. Comorbid schizophrenia with NT1 in the Slovakian Narcolepsy Database was within the prevalence expected in the general population. The solitary psychotic episode in the course of NT1 did not reduce the possibility of subsequent symptomatic treatment afterwards.https://www.mdpi.com/2076-3425/13/1/43psychotic episodeschizophrenianarcolepsyhypocretin deficiency |
| spellingShingle | Eva Feketeová Jozef Dragašek Katarína Klobučníková Peter Ďurdík Simona Čarnakovič Miriam Slavkovská Martina Chylová Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database Brain Sciences psychotic episode schizophrenia narcolepsy hypocretin deficiency |
| title | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
| title_full | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
| title_fullStr | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
| title_full_unstemmed | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
| title_short | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
| title_sort | psychotic episode and schizophrenia in slovakian narcolepsy database |
| topic | psychotic episode schizophrenia narcolepsy hypocretin deficiency |
| url | https://www.mdpi.com/2076-3425/13/1/43 |
| work_keys_str_mv | AT evafeketeova psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT jozefdragasek psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT katarinaklobucnikova psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT peterdurdik psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT simonacarnakovic psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT miriamslavkovska psychoticepisodeandschizophreniainslovakiannarcolepsydatabase AT martinachylova psychoticepisodeandschizophreniainslovakiannarcolepsydatabase |