Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity

Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity

Infectious disease remains a substantial cause of death. To overcome this issue, mucosal vaccine systems are considered to be a promising strategy. Yet, none are approved for clinical use, except for live-attenuated mucosal vaccines, mainly owing to the lack of effective and safe systems to induce a...

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Bibliographic Details
Main Authors: Rui Tada, Akihiro Ohshima, Yuya Tanazawa, Akari Ohmi, Saeko Takahashi, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki, Yoichi Negishi
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Vaccines
Subjects:
cationic liposome
damps
dsdna
dying cells
mucosal adjuvant
Online Access:https://www.mdpi.com/2076-393X/8/1/8

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