Primary headache types in adult epilepsy patients
Abstract Background Headache is among the most common comorbidities in epilepsy. This study examined the distribution of different primary headache disorders in a large cohort of patients with diagnosed epilepsy. Headache types were analysed with regard to gender, type of epilepsy and antiepileptic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01023-8 |
| _version_ | 1811175923692601344 |
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| author | Katharina Schiller Markus Rauchenzauner Tamir Avidgor Sana Hannan Carlo Lorenzen Manuela Kaml Gerald Walser Iris Unterberger Vera Filippi Gregor Broessner Gerhard Luef |
| author_facet | Katharina Schiller Markus Rauchenzauner Tamir Avidgor Sana Hannan Carlo Lorenzen Manuela Kaml Gerald Walser Iris Unterberger Vera Filippi Gregor Broessner Gerhard Luef |
| author_sort | Katharina Schiller |
| collection | DOAJ |
| description | Abstract Background Headache is among the most common comorbidities in epilepsy. This study examined the distribution of different primary headache disorders in a large cohort of patients with diagnosed epilepsy. Headache types were analysed with regard to gender, type of epilepsy and antiepileptic drugs (AEDs). Methods In this prospective single-centre study, 500 patients with epilepsy (250 female, mean age: 45.52 ± 17.26 years) were evaluated with regards to primary headache types using a validated German headache questionnaire categorizing for migraine (MIG), tension-type headache (TTH) or trigeminal autonomic cephalalgias (TAC), their combinations and unclassifiable headache. Data regarding type of epilepsy, seizure-associated headache, AED treatment and seizure freedom were collected. Results Of 500 patients with epilepsy, 163 (32.6%) patients (108 female and 55 male) reported suffering from headaches at least 1 day per month. MIG (without aura, with aura) and TTH were the most frequent headache type (MIG 33.1%, TTH 33.1%). Female epilepsy patients reported headaches significantly more often than male patients (x 2 = 8.20, p = 0.0042). In contrast, the type of epilepsy did not significantly affect headache distribution. Of 163 patients with headache, 66 (40.5%) patients reported seizure-associated headache and AEDs were used by 157 patients. Of importance, patients with AED monotherapy suffered from MIG less often when compared to patients on polytherapy (x 2 = 4.79, p = 0.028). Conclusion MIG and TTH are the most common headache types in epilepsy patients and headache is more frequent among female epilepsy patients. Monotherapy in AEDs might have a beneficial effect on the frequency of headache compared to polytherapy. |
| first_indexed | 2024-04-10T19:43:50Z |
| format | Article |
| id | doaj.art-1b0ce15375a74a43811b9cd9ed68b3ac |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-10T19:43:50Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-1b0ce15375a74a43811b9cd9ed68b3ac2023-01-29T12:07:34ZengBMCEuropean Journal of Medical Research2047-783X2023-01-012811710.1186/s40001-023-01023-8Primary headache types in adult epilepsy patientsKatharina Schiller0Markus Rauchenzauner1Tamir Avidgor2Sana Hannan3Carlo Lorenzen4Manuela Kaml5Gerald Walser6Iris Unterberger7Vera Filippi8Gregor Broessner9Gerhard Luef10Department of Pediatrics and Neonatology, Hospital OstallgaeuDepartment of Pediatrics and Neonatology, Hospital OstallgaeuAnalytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill UniversityAnalytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill UniversityDepartment of Neurology, Epilepsy Unit, Medical University InnsbruckDepartment of Neurology, Epilepsy Unit, Medical University InnsbruckDepartment of Neurology, Epilepsy Unit, Medical University InnsbruckDepartment of Neurology, Epilepsy Unit, Medical University InnsbruckDepartment of Neurology, Headache Outpatient Clinic, Medical University InnsbruckDepartment of Neurology, Headache Outpatient Clinic, Medical University InnsbruckDepartment of Neurology, Epilepsy Unit, Medical University InnsbruckAbstract Background Headache is among the most common comorbidities in epilepsy. This study examined the distribution of different primary headache disorders in a large cohort of patients with diagnosed epilepsy. Headache types were analysed with regard to gender, type of epilepsy and antiepileptic drugs (AEDs). Methods In this prospective single-centre study, 500 patients with epilepsy (250 female, mean age: 45.52 ± 17.26 years) were evaluated with regards to primary headache types using a validated German headache questionnaire categorizing for migraine (MIG), tension-type headache (TTH) or trigeminal autonomic cephalalgias (TAC), their combinations and unclassifiable headache. Data regarding type of epilepsy, seizure-associated headache, AED treatment and seizure freedom were collected. Results Of 500 patients with epilepsy, 163 (32.6%) patients (108 female and 55 male) reported suffering from headaches at least 1 day per month. MIG (without aura, with aura) and TTH were the most frequent headache type (MIG 33.1%, TTH 33.1%). Female epilepsy patients reported headaches significantly more often than male patients (x 2 = 8.20, p = 0.0042). In contrast, the type of epilepsy did not significantly affect headache distribution. Of 163 patients with headache, 66 (40.5%) patients reported seizure-associated headache and AEDs were used by 157 patients. Of importance, patients with AED monotherapy suffered from MIG less often when compared to patients on polytherapy (x 2 = 4.79, p = 0.028). Conclusion MIG and TTH are the most common headache types in epilepsy patients and headache is more frequent among female epilepsy patients. Monotherapy in AEDs might have a beneficial effect on the frequency of headache compared to polytherapy.https://doi.org/10.1186/s40001-023-01023-8HeadacheEpilepsyAEDMigraineTension-type headache |
| spellingShingle | Katharina Schiller Markus Rauchenzauner Tamir Avidgor Sana Hannan Carlo Lorenzen Manuela Kaml Gerald Walser Iris Unterberger Vera Filippi Gregor Broessner Gerhard Luef Primary headache types in adult epilepsy patients European Journal of Medical Research Headache Epilepsy AED Migraine Tension-type headache |
| title | Primary headache types in adult epilepsy patients |
| title_full | Primary headache types in adult epilepsy patients |
| title_fullStr | Primary headache types in adult epilepsy patients |
| title_full_unstemmed | Primary headache types in adult epilepsy patients |
| title_short | Primary headache types in adult epilepsy patients |
| title_sort | primary headache types in adult epilepsy patients |
| topic | Headache Epilepsy AED Migraine Tension-type headache |
| url | https://doi.org/10.1186/s40001-023-01023-8 |
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