Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations
Inflammatory bowel disease (IBD) is a chronic inflammatory disease typically involving the gastrointestinal tract but not limited to it. IBD can be subdivided into Crohn’s disease (CD) and ulcerative colitis (UC). Extraintestinal manifestations (EIMs) are observed in up to 47% of patients with IBD,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234535/full |
| _version_ | 1827782774825680896 |
|---|---|
| author | Ronghua He Subei Zhao Mingyu Cui Yanhao Chen Jinrong Ma Jintao Li Xiaodong Wang |
| author_facet | Ronghua He Subei Zhao Mingyu Cui Yanhao Chen Jinrong Ma Jintao Li Xiaodong Wang |
| author_sort | Ronghua He |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory disease typically involving the gastrointestinal tract but not limited to it. IBD can be subdivided into Crohn’s disease (CD) and ulcerative colitis (UC). Extraintestinal manifestations (EIMs) are observed in up to 47% of patients with IBD, with the most frequent reports of cutaneous manifestations. Among these, pyoderma gangrenosum (PG) and erythema nodosum (EN) are the two most common skin manifestations in IBD, and both are immune-related inflammatory skin diseases. The presence of cutaneous EIMs may either be concordant with intestinal disease activity or have an independent course. Despite some progress in research on EIMs, for instance, ectopic expression of gut-specific mucosal address cell adhesion molecule-1 (MAdCAM-1) and chemokine CCL25 on the vascular endothelium of the portal tract have been demonstrated in IBD-related primary sclerosing cholangitis (PSC), little is understood about the potential pathophysiological associations between IBD and cutaneous EIMs. Whether cutaneous EIMs are inflammatory events with a commonly shared genetic background or environmental risk factors with IBD but independent of IBD or are the result of an extraintestinal extension of intestinal inflammation, remains unclear. The review aims to provide an overview of the two most representative cutaneous manifestations of IBD, describe IBD’s epidemiology, clinical characteristics, and histology, and discuss the immunopathophysiology and existing treatment strategies with biologic agents, with a focus on the potential pathophysiological associations between IBD and cutaneous EIMs. |
| first_indexed | 2024-03-11T15:37:50Z |
| format | Article |
| id | doaj.art-1b10048c4a644dadb006a84a5588193b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T15:37:50Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1b10048c4a644dadb006a84a5588193b2023-10-26T13:14:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12345351234535Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associationsRonghua He0Subei Zhao1Mingyu Cui2Yanhao Chen3Jinrong Ma4Jintao Li5Xiaodong Wang6Department of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gastroenterology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaInflammatory bowel disease (IBD) is a chronic inflammatory disease typically involving the gastrointestinal tract but not limited to it. IBD can be subdivided into Crohn’s disease (CD) and ulcerative colitis (UC). Extraintestinal manifestations (EIMs) are observed in up to 47% of patients with IBD, with the most frequent reports of cutaneous manifestations. Among these, pyoderma gangrenosum (PG) and erythema nodosum (EN) are the two most common skin manifestations in IBD, and both are immune-related inflammatory skin diseases. The presence of cutaneous EIMs may either be concordant with intestinal disease activity or have an independent course. Despite some progress in research on EIMs, for instance, ectopic expression of gut-specific mucosal address cell adhesion molecule-1 (MAdCAM-1) and chemokine CCL25 on the vascular endothelium of the portal tract have been demonstrated in IBD-related primary sclerosing cholangitis (PSC), little is understood about the potential pathophysiological associations between IBD and cutaneous EIMs. Whether cutaneous EIMs are inflammatory events with a commonly shared genetic background or environmental risk factors with IBD but independent of IBD or are the result of an extraintestinal extension of intestinal inflammation, remains unclear. The review aims to provide an overview of the two most representative cutaneous manifestations of IBD, describe IBD’s epidemiology, clinical characteristics, and histology, and discuss the immunopathophysiology and existing treatment strategies with biologic agents, with a focus on the potential pathophysiological associations between IBD and cutaneous EIMs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234535/fullinflammatory bowel diseaseCrohn’s diseaseulcerative colitisextraintestinal manifestations (EIMs)cutaneous manifestationspathophysiological associations |
| spellingShingle | Ronghua He Subei Zhao Mingyu Cui Yanhao Chen Jinrong Ma Jintao Li Xiaodong Wang Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations Frontiers in Immunology inflammatory bowel disease Crohn’s disease ulcerative colitis extraintestinal manifestations (EIMs) cutaneous manifestations pathophysiological associations |
| title | Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations |
| title_full | Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations |
| title_fullStr | Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations |
| title_full_unstemmed | Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations |
| title_short | Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations |
| title_sort | cutaneous manifestations of inflammatory bowel disease basic characteristics therapy and potential pathophysiological associations |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis extraintestinal manifestations (EIMs) cutaneous manifestations pathophysiological associations |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234535/full |
| work_keys_str_mv | AT ronghuahe cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT subeizhao cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT mingyucui cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT yanhaochen cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT jinrongma cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT jintaoli cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations AT xiaodongwang cutaneousmanifestationsofinflammatoryboweldiseasebasiccharacteristicstherapyandpotentialpathophysiologicalassociations |