Diagnosis and Management of Neuropathic Pain in Spine Diseases
Neuropathic pain is generally defined as a non-physiological pain experience caused by damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus, or independently of its action, leading to unusual pain sensations usually referred to as firing, burning or throbbing....
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1380 |
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| author | Joanna Bielewicz Maciej Kamieniak Michał Szymoniuk Jakub Litak Wojciech Czyżewski Piotr Kamieniak |
| author_facet | Joanna Bielewicz Maciej Kamieniak Michał Szymoniuk Jakub Litak Wojciech Czyżewski Piotr Kamieniak |
| author_sort | Joanna Bielewicz |
| collection | DOAJ |
| description | Neuropathic pain is generally defined as a non-physiological pain experience caused by damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus, or independently of its action, leading to unusual pain sensations usually referred to as firing, burning or throbbing. In the course of spine disorders, pain symptoms commonly occur. According to available epidemiological studies, a neuropathic component of pain is often present in patients with spinal diseases, with a frequency ranging from 36% to 55% of patients. Distinguishing between chronic nociceptive pain and neuropathic pain very often remains a challenge. Consequently, neuropathic pain is often underdiagnosed in patients with spinal diseases. In reference to current guidelines for the treatment of neuropathic pain, gabapentin, serotonin and norepinephrine reuptake inhibitors and tricyclic antidepressants constitute first-line therapeutic agents. However, long-term pharmacologic treatment often leads to developing tolerance and resistance to used medications. Therefore, in recent years, a plethora of therapeutic methods for neuropathic pain have been developed and investigated to improve clinical outcomes. In this review, we briefly summarized current knowledge about the pathophysiology and diagnosis of neuropathic pain. Moreover, we described the most effective treatment approaches for neuropathic pain and discussed their relevance in the treatment of spinal pain. |
| first_indexed | 2024-03-11T08:38:24Z |
| format | Article |
| id | doaj.art-1b10cafb221446d48ce687f4fe9b0d5e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:24Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-1b10cafb221446d48ce687f4fe9b0d5e2023-11-16T21:18:45ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124138010.3390/jcm12041380Diagnosis and Management of Neuropathic Pain in Spine DiseasesJoanna Bielewicz0Maciej Kamieniak1Michał Szymoniuk2Jakub Litak3Wojciech Czyżewski4Piotr Kamieniak5Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandNeuropathic pain is generally defined as a non-physiological pain experience caused by damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus, or independently of its action, leading to unusual pain sensations usually referred to as firing, burning or throbbing. In the course of spine disorders, pain symptoms commonly occur. According to available epidemiological studies, a neuropathic component of pain is often present in patients with spinal diseases, with a frequency ranging from 36% to 55% of patients. Distinguishing between chronic nociceptive pain and neuropathic pain very often remains a challenge. Consequently, neuropathic pain is often underdiagnosed in patients with spinal diseases. In reference to current guidelines for the treatment of neuropathic pain, gabapentin, serotonin and norepinephrine reuptake inhibitors and tricyclic antidepressants constitute first-line therapeutic agents. However, long-term pharmacologic treatment often leads to developing tolerance and resistance to used medications. Therefore, in recent years, a plethora of therapeutic methods for neuropathic pain have been developed and investigated to improve clinical outcomes. In this review, we briefly summarized current knowledge about the pathophysiology and diagnosis of neuropathic pain. Moreover, we described the most effective treatment approaches for neuropathic pain and discussed their relevance in the treatment of spinal pain.https://www.mdpi.com/2077-0383/12/4/1380neuropathic painneuralgiapathophysiologytherapeuticsspinal diseases |
| spellingShingle | Joanna Bielewicz Maciej Kamieniak Michał Szymoniuk Jakub Litak Wojciech Czyżewski Piotr Kamieniak Diagnosis and Management of Neuropathic Pain in Spine Diseases Journal of Clinical Medicine neuropathic pain neuralgia pathophysiology therapeutics spinal diseases |
| title | Diagnosis and Management of Neuropathic Pain in Spine Diseases |
| title_full | Diagnosis and Management of Neuropathic Pain in Spine Diseases |
| title_fullStr | Diagnosis and Management of Neuropathic Pain in Spine Diseases |
| title_full_unstemmed | Diagnosis and Management of Neuropathic Pain in Spine Diseases |
| title_short | Diagnosis and Management of Neuropathic Pain in Spine Diseases |
| title_sort | diagnosis and management of neuropathic pain in spine diseases |
| topic | neuropathic pain neuralgia pathophysiology therapeutics spinal diseases |
| url | https://www.mdpi.com/2077-0383/12/4/1380 |
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