Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure
<p>Abstract</p> <p>Background</p> <p>Assessment of human exposure to non-persistent pesticides such as pyrethroids is often based on urinary biomarker measurements. Urinary metabolite levels of these pesticides are usually reported in volume-weighted concentrations or c...
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| Format: | Article |
| Language: | English |
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BMC
2008-11-01
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| Series: | Environmental Health |
| Online Access: | http://www.ehjournal.net/content/7/1/55 |
| _version_ | 1811259831180328960 |
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| author | Bouchard Michèle Carrier Gaétan Fortin Marie-Chantale |
| author_facet | Bouchard Michèle Carrier Gaétan Fortin Marie-Chantale |
| author_sort | Bouchard Michèle |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Assessment of human exposure to non-persistent pesticides such as pyrethroids is often based on urinary biomarker measurements. Urinary metabolite levels of these pesticides are usually reported in volume-weighted concentrations or creatinine-adjusted concentrations measured in spot urine samples. It is known that these units are subject to intra- and inter-individual variations. This research aimed at studying the impact of these variations on the assessment of pyrethroid absorbed doses at individual and population levels.</p> <p>Methods</p> <p>Using data obtained from various adult and infantile populations, the intra and inter-individual variability in the urinary flow rate and creatinine excretion rate was first estimated. Individual absorbed doses were then calculated using volume-weighted or creatinine-adjusted concentrations according to published approaches and compared to those estimated from the amounts of biomarkers excreted in 15- or 24-h urine collections, the latter serving as a benchmark unit. The effect of the units of measurements (volume-weighted or creatinine adjusted concentrations or 24-h amounts) on results of the comparison of pyrethroid biomarker levels between two populations was also evaluated.</p> <p>Results</p> <p>Estimation of daily absorbed doses of permethrin from volume-weighted or creatinine-adjusted concentrations of biomarkers was found to potentially lead to substantial under or overestimation when compared to doses reconstructed directly from amounts excreted in urine during a given period of time (-70 to +573% and -83 to +167%, respectively). It was also shown that the variability in creatinine excretion rate and urinary flow rate may introduce a bias in the case of between population comparisons.</p> <p>Conclusion</p> <p>The unit chosen to express biomonitoring data may influence the validity of estimated individual absorbed dose as well as the outcome of between population comparisons.</p> |
| first_indexed | 2024-04-12T18:38:28Z |
| format | Article |
| id | doaj.art-1b1280cdcc9c4139a992beaa50f4b597 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-12T18:38:28Z |
| publishDate | 2008-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-1b1280cdcc9c4139a992beaa50f4b5972022-12-22T03:20:52ZengBMCEnvironmental Health1476-069X2008-11-01715510.1186/1476-069X-7-55Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposureBouchard MichèleCarrier GaétanFortin Marie-Chantale<p>Abstract</p> <p>Background</p> <p>Assessment of human exposure to non-persistent pesticides such as pyrethroids is often based on urinary biomarker measurements. Urinary metabolite levels of these pesticides are usually reported in volume-weighted concentrations or creatinine-adjusted concentrations measured in spot urine samples. It is known that these units are subject to intra- and inter-individual variations. This research aimed at studying the impact of these variations on the assessment of pyrethroid absorbed doses at individual and population levels.</p> <p>Methods</p> <p>Using data obtained from various adult and infantile populations, the intra and inter-individual variability in the urinary flow rate and creatinine excretion rate was first estimated. Individual absorbed doses were then calculated using volume-weighted or creatinine-adjusted concentrations according to published approaches and compared to those estimated from the amounts of biomarkers excreted in 15- or 24-h urine collections, the latter serving as a benchmark unit. The effect of the units of measurements (volume-weighted or creatinine adjusted concentrations or 24-h amounts) on results of the comparison of pyrethroid biomarker levels between two populations was also evaluated.</p> <p>Results</p> <p>Estimation of daily absorbed doses of permethrin from volume-weighted or creatinine-adjusted concentrations of biomarkers was found to potentially lead to substantial under or overestimation when compared to doses reconstructed directly from amounts excreted in urine during a given period of time (-70 to +573% and -83 to +167%, respectively). It was also shown that the variability in creatinine excretion rate and urinary flow rate may introduce a bias in the case of between population comparisons.</p> <p>Conclusion</p> <p>The unit chosen to express biomonitoring data may influence the validity of estimated individual absorbed dose as well as the outcome of between population comparisons.</p>http://www.ehjournal.net/content/7/1/55 |
| spellingShingle | Bouchard Michèle Carrier Gaétan Fortin Marie-Chantale Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure Environmental Health |
| title | Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure |
| title_full | Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure |
| title_fullStr | Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure |
| title_full_unstemmed | Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure |
| title_short | Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure |
| title_sort | concentrations versus amounts of biomarkers in urine a comparison of approaches to assess pyrethroid exposure |
| url | http://www.ehjournal.net/content/7/1/55 |
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