Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ

Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ

Abstract Background Imeglimin is a new anti-diabetic drug which promotes insulin secretion from pancreatic β-cells and reduces insulin resistance in insulin target tissues. However, there have been no reports examining the possible anti-atherosclerotic effects of imeglimin. In this study, we investi...

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Main Authors: Junpei Sanada, Tomohiko Kimura, Masashi Shimoda, Yuichiro Iwamoto, Hideyuki Iwamoto, Kazunori Dan, Yoshiro Fushimi, Yukino Katakura, Yuka Nogami, Yoshiko Shirakiya, Yuki Yamasaki, Tomoko Ikeda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cardiovascular Diabetology
Subjects:
Imeglimin
Type 2 diabetes mellitus
Atherosclerosis
Oxidative stress
Inflammation
Online Access:https://doi.org/10.1186/s12933-024-02189-z

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