Melatonin and cancer suppression: insights into its effects on DNA methylation
Abstract Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regulation of circadian rhythms, which is important for optimal human health. Also, melatonin has a broad range of immunoenhancing actions. Moreover, its oncostatic properties...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-022-00375-z |
| _version_ | 1811211832398970880 |
|---|---|
| author | Amirhossein Davoodvandi Banafsheh Nikfar Russel J. Reiter Zatollah Asemi |
| author_facet | Amirhossein Davoodvandi Banafsheh Nikfar Russel J. Reiter Zatollah Asemi |
| author_sort | Amirhossein Davoodvandi |
| collection | DOAJ |
| description | Abstract Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regulation of circadian rhythms, which is important for optimal human health. Also, melatonin has a broad range of immunoenhancing actions. Moreover, its oncostatic properties, especially regarding breast cancer, involve a variety cancer-inhibitory processes and are well documented. Due to their promising effects on the prognosis of cancer patients, anti-cancer drugs with epigenetic actions have attracted a significant amount of attention in recent years. Epigenetic modifications of cancers are categorized into three major processes including non-coding RNAs, histone modification, and DNA methylation. Hence, the modification of the latter epigenetic event is currently considered an effective strategy for treatment of cancer patients. Thereby, this report summarizes the available evidence that investigated melatonin-induced effects in altering the status of DNA methylation in different cancer cells and models, e.g., malignant glioma and breast carcinoma. Also, we discuss the role of artificial light at night (ALAN)-mediated inhibitory effects on melatonin secretion and subsequent impact on global DNA methylation of cancer cells. |
| first_indexed | 2024-04-12T05:18:53Z |
| format | Article |
| id | doaj.art-1b14b839504b4a77af028a09fe6090c2 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-04-12T05:18:53Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-1b14b839504b4a77af028a09fe6090c22022-12-22T03:46:33ZengBMCCellular & Molecular Biology Letters1425-81531689-13922022-09-0127111110.1186/s11658-022-00375-zMelatonin and cancer suppression: insights into its effects on DNA methylationAmirhossein Davoodvandi0Banafsheh Nikfar1Russel J. Reiter2Zatollah Asemi3Student Research Committee, Kashan University of Medical SciencesPars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical SciencesDepartment of Cell Systems and Anatomy, UT Health. Long School of MedicineResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesAbstract Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regulation of circadian rhythms, which is important for optimal human health. Also, melatonin has a broad range of immunoenhancing actions. Moreover, its oncostatic properties, especially regarding breast cancer, involve a variety cancer-inhibitory processes and are well documented. Due to their promising effects on the prognosis of cancer patients, anti-cancer drugs with epigenetic actions have attracted a significant amount of attention in recent years. Epigenetic modifications of cancers are categorized into three major processes including non-coding RNAs, histone modification, and DNA methylation. Hence, the modification of the latter epigenetic event is currently considered an effective strategy for treatment of cancer patients. Thereby, this report summarizes the available evidence that investigated melatonin-induced effects in altering the status of DNA methylation in different cancer cells and models, e.g., malignant glioma and breast carcinoma. Also, we discuss the role of artificial light at night (ALAN)-mediated inhibitory effects on melatonin secretion and subsequent impact on global DNA methylation of cancer cells.https://doi.org/10.1186/s11658-022-00375-zMelatoninDNA methylationDNMTEpigenetics |
| spellingShingle | Amirhossein Davoodvandi Banafsheh Nikfar Russel J. Reiter Zatollah Asemi Melatonin and cancer suppression: insights into its effects on DNA methylation Cellular & Molecular Biology Letters Melatonin DNA methylation DNMT Epigenetics |
| title | Melatonin and cancer suppression: insights into its effects on DNA methylation |
| title_full | Melatonin and cancer suppression: insights into its effects on DNA methylation |
| title_fullStr | Melatonin and cancer suppression: insights into its effects on DNA methylation |
| title_full_unstemmed | Melatonin and cancer suppression: insights into its effects on DNA methylation |
| title_short | Melatonin and cancer suppression: insights into its effects on DNA methylation |
| title_sort | melatonin and cancer suppression insights into its effects on dna methylation |
| topic | Melatonin DNA methylation DNMT Epigenetics |
| url | https://doi.org/10.1186/s11658-022-00375-z |
| work_keys_str_mv | AT amirhosseindavoodvandi melatoninandcancersuppressioninsightsintoitseffectsondnamethylation AT banafshehnikfar melatoninandcancersuppressioninsightsintoitseffectsondnamethylation AT russeljreiter melatoninandcancersuppressioninsightsintoitseffectsondnamethylation AT zatollahasemi melatoninandcancersuppressioninsightsintoitseffectsondnamethylation |