Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease
The persistence or recurrence of symptoms in patients with coeliac disease (CD), despite a gluten-free diet (GFD), must prompt further work-up for excluding refractory CD (RCD). The aim of this study was to assess the accuracy of serum markers in predicting refractoriness in CD patients. This study...
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/10/2289 |
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| author | Marco Vincenzo Lenti Nicola Aronico Paolo Giuffrida Valentina Antoci Giovanni Santacroce Alessandro Vanoli Catherine Klersy Gino Roberto Corazza Antonio Di Sabatino |
| author_facet | Marco Vincenzo Lenti Nicola Aronico Paolo Giuffrida Valentina Antoci Giovanni Santacroce Alessandro Vanoli Catherine Klersy Gino Roberto Corazza Antonio Di Sabatino |
| author_sort | Marco Vincenzo Lenti |
| collection | DOAJ |
| description | The persistence or recurrence of symptoms in patients with coeliac disease (CD), despite a gluten-free diet (GFD), must prompt further work-up for excluding refractory CD (RCD). The aim of this study was to assess the accuracy of serum markers in predicting refractoriness in CD patients. This study included 72 patients affected by CD followed-up at our center, namely 49 uncomplicated CD before and after GFD and 23 RCD. Serum levels of chromogranin A (CgA) and β2-microglobuline were measured at baseline and at follow-up (median time of 13 months) in each group of patients. Cut-off points for each marker were estimated to differentiate RCD from uncomplicated CD patients. Serum levels of CgA and β2-microglobuline were significantly higher in patients with RCD compared to uncomplicated CD (<i>p</i> < 0.001), both at baseline and at follow-up, with no significant difference between RCD type 1 and type 2. The estimated cut-off point for CgA was 90.2 ng/mL (sensitivity 83%, specificity 100%), while for β2-microglobuline it was 696 mcg/L (sensitivity 100%, specificity of 100%). To conclude, CgA and β2-microglobuline could be useful serological markers of refractoriness in CD, with the ability to discriminate those patients who should undergo upper gastrointestinal endoscopy for making a definite diagnosis. |
| first_indexed | 2024-03-10T11:32:25Z |
| format | Article |
| id | doaj.art-1b14c96cadab4bf0be242901f6a9b2ea |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:32:25Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1b14c96cadab4bf0be242901f6a9b2ea2023-11-21T19:07:25ZengMDPI AGCancers2072-66942021-05-011310228910.3390/cancers13102289Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac DiseaseMarco Vincenzo Lenti0Nicola Aronico1Paolo Giuffrida2Valentina Antoci3Giovanni Santacroce4Alessandro Vanoli5Catherine Klersy6Gino Roberto Corazza7Antonio Di Sabatino8Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyAnatomic Pathology Unit, IRCCS San Matteo Hospital Foundation, Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyClinical Epidemiology and Biometry, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyDepartment of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, ItalyThe persistence or recurrence of symptoms in patients with coeliac disease (CD), despite a gluten-free diet (GFD), must prompt further work-up for excluding refractory CD (RCD). The aim of this study was to assess the accuracy of serum markers in predicting refractoriness in CD patients. This study included 72 patients affected by CD followed-up at our center, namely 49 uncomplicated CD before and after GFD and 23 RCD. Serum levels of chromogranin A (CgA) and β2-microglobuline were measured at baseline and at follow-up (median time of 13 months) in each group of patients. Cut-off points for each marker were estimated to differentiate RCD from uncomplicated CD patients. Serum levels of CgA and β2-microglobuline were significantly higher in patients with RCD compared to uncomplicated CD (<i>p</i> < 0.001), both at baseline and at follow-up, with no significant difference between RCD type 1 and type 2. The estimated cut-off point for CgA was 90.2 ng/mL (sensitivity 83%, specificity 100%), while for β2-microglobuline it was 696 mcg/L (sensitivity 100%, specificity of 100%). To conclude, CgA and β2-microglobuline could be useful serological markers of refractoriness in CD, with the ability to discriminate those patients who should undergo upper gastrointestinal endoscopy for making a definite diagnosis.https://www.mdpi.com/2072-6694/13/10/2289β2-microglobulinechromogranin Arefractory coeliac diseaseserum markers |
| spellingShingle | Marco Vincenzo Lenti Nicola Aronico Paolo Giuffrida Valentina Antoci Giovanni Santacroce Alessandro Vanoli Catherine Klersy Gino Roberto Corazza Antonio Di Sabatino Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease Cancers β2-microglobuline chromogranin A refractory coeliac disease serum markers |
| title | Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease |
| title_full | Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease |
| title_fullStr | Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease |
| title_full_unstemmed | Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease |
| title_short | Serum Markers of Refractoriness and Enteropathy-Associated T-Cell Lymphoma in Coeliac Disease |
| title_sort | serum markers of refractoriness and enteropathy associated t cell lymphoma in coeliac disease |
| topic | β2-microglobuline chromogranin A refractory coeliac disease serum markers |
| url | https://www.mdpi.com/2072-6694/13/10/2289 |
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