Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. Th...

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Bibliographic Details
Main Authors: Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, Michael B Stout
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
17α-estradiol
aging
estrogen receptor
hypothalamus
metabolism
obesity
Online Access:https://elifesciences.org/articles/59616

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