Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain
The oil of the Unani medicinal herb Baboona (<i>Matricaria chamomilla</i>) has shown potential in the management of pain. However, predicaments such as poor skin penetration, skin sensitization, liable to degradation, and volatile nature restrict its use. Therefore, our group for the fir...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/9/10/794 |
| _version_ | 1797573743959080960 |
|---|---|
| author | Amit Sah Geeta Aggarwal Gaurav K. Jain Syed Mohammad Abbas Zaidi Punnoth Poonkuzhi Naseef Mohamed S. Kuruniyan Foziyah Zakir |
| author_facet | Amit Sah Geeta Aggarwal Gaurav K. Jain Syed Mohammad Abbas Zaidi Punnoth Poonkuzhi Naseef Mohamed S. Kuruniyan Foziyah Zakir |
| author_sort | Amit Sah |
| collection | DOAJ |
| description | The oil of the Unani medicinal herb Baboona (<i>Matricaria chamomilla</i>) has shown potential in the management of pain. However, predicaments such as poor skin penetration, skin sensitization, liable to degradation, and volatile nature restrict its use. Therefore, our group for the first time has developed a carrier-based delivery system to facilitate the direct application of chamomile oil to the forehead. The developed nanogel was characterized for physical parameters such as compatibility, TEM, and stability studies. Further, it was also evaluated for pH, viscosity, spread ability, and extrudability, as well as through texture analyses, in vitro studies, and skin irritation tests. The formulation was successfully developed with all the necessary attributes. The in vitro studies revealed the enhanced skin penetration of chamomile oil nanogel. The in vivo studies were also performed in chemically induced pain models, mimicking migraine. The studies show significant improvement of the pain threshold for chamomile nanogel when compared to the positive control group and the results were comparable to marketed diclofenac formulations. Finally, the encapsulation into nanogel reduced the skin irritation property. The nanogel formulation showed promising effects in the pain management of migraine. |
| first_indexed | 2024-03-10T21:13:24Z |
| format | Article |
| id | doaj.art-1b156009393944f7a64d0b194ba226f6 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T21:13:24Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-1b156009393944f7a64d0b194ba226f62023-11-19T16:35:27ZengMDPI AGGels2310-28612023-10-0191079410.3390/gels9100794Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of PainAmit Sah0Geeta Aggarwal1Gaurav K. Jain2Syed Mohammad Abbas Zaidi3Punnoth Poonkuzhi Naseef4Mohamed S. Kuruniyan5Foziyah Zakir6Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University, Sector-3, M.B. Road, Pushp Vihar, New Delhi 110017, IndiaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Sector-3, M.B. Road, Pushp Vihar, New Delhi 110017, IndiaDepartment of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University, Sector-3, M.B. Road, Pushp Vihar, New Delhi 110017, IndiaDepartment of Moalajat (Internal Medicine), Hakim Syed Zia ul Hasan (HSZH) Govt. Unani Medical College, Bhopal 462003, IndiaDepartment of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna Kerala 679321, IndiaDepartment of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi ArabiaDepartment of B.Pharm (Ayurveda), School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Sector-3, M.B. Road, Pushp Vihar, New Delhi 110017, IndiaThe oil of the Unani medicinal herb Baboona (<i>Matricaria chamomilla</i>) has shown potential in the management of pain. However, predicaments such as poor skin penetration, skin sensitization, liable to degradation, and volatile nature restrict its use. Therefore, our group for the first time has developed a carrier-based delivery system to facilitate the direct application of chamomile oil to the forehead. The developed nanogel was characterized for physical parameters such as compatibility, TEM, and stability studies. Further, it was also evaluated for pH, viscosity, spread ability, and extrudability, as well as through texture analyses, in vitro studies, and skin irritation tests. The formulation was successfully developed with all the necessary attributes. The in vitro studies revealed the enhanced skin penetration of chamomile oil nanogel. The in vivo studies were also performed in chemically induced pain models, mimicking migraine. The studies show significant improvement of the pain threshold for chamomile nanogel when compared to the positive control group and the results were comparable to marketed diclofenac formulations. Finally, the encapsulation into nanogel reduced the skin irritation property. The nanogel formulation showed promising effects in the pain management of migraine.https://www.mdpi.com/2310-2861/9/10/794Baboonachamomile<i>Matricaria chamomilla</i>migrainenanogelnanoemulsion |
| spellingShingle | Amit Sah Geeta Aggarwal Gaurav K. Jain Syed Mohammad Abbas Zaidi Punnoth Poonkuzhi Naseef Mohamed S. Kuruniyan Foziyah Zakir Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain Gels Baboona chamomile <i>Matricaria chamomilla</i> migraine nanogel nanoemulsion |
| title | Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain |
| title_full | Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain |
| title_fullStr | Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain |
| title_full_unstemmed | Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain |
| title_short | Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain |
| title_sort | design and development of a topical nanogel formulation comprising of a unani medicinal agent for the management of pain |
| topic | Baboona chamomile <i>Matricaria chamomilla</i> migraine nanogel nanoemulsion |
| url | https://www.mdpi.com/2310-2861/9/10/794 |
| work_keys_str_mv | AT amitsah designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT geetaaggarwal designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT gauravkjain designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT syedmohammadabbaszaidi designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT punnothpoonkuzhinaseef designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT mohamedskuruniyan designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain AT foziyahzakir designanddevelopmentofatopicalnanogelformulationcomprisingofaunanimedicinalagentforthemanagementofpain |