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Introduction and objective: pancreatic endocrine tumors (PET) are difficult to diagnose. Their accurate localization using imaging techniques is intended to provide a definite cure. The goal of this retrospective study was to review a PET series from a private institution. Patients and methods: the...
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| Format: | Article |
| Language: | English |
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Aran Ediciones
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| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082011000400003&lng=en&tlng=en |
| _version_ | 1819242508939427840 |
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| author | Modesto Varas Joan Gornals José María Ponseti Antonio Alastruè Cristina Durán Carlos Llevaria Carlos Ballesta Alberto Díez Caballero Vicente Artigas |
| author_facet | Modesto Varas Joan Gornals José María Ponseti Antonio Alastruè Cristina Durán Carlos Llevaria Carlos Ballesta Alberto Díez Caballero Vicente Artigas |
| author_sort | Modesto Varas |
| collection | DOAJ |
| description | Introduction and objective: pancreatic endocrine tumors (PET) are difficult to diagnose. Their accurate localization using imaging techniques is intended to provide a definite cure. The goal of this retrospective study was to review a PET series from a private institution. Patients and methods: the medical records of 19 patients with PETs were reviewed, including 4 cases of MEN-1, for a period of 17 years (1994-2010). A database was set up with ten parameters: age, sex, symptoms, imaging techniques, size and location in the pancreas, metastasis, surgery, complications, adjuvant therapies, definite diagnosis, and survival or death. Results: a total of 19 cases were analyzed. Mean age at presentation was 51 years (range: 26-67 y) (14 males, 5 females), and tumor size was 5 to 80 mm (X: 20 mm). Metastatic disease was present in 37% (7/19). Most underwent the following imaging techniques: ultrasounds, computed tomography (CT) and magnetic resonance imaging (MRI). Fine needle aspiration punction (FNA) was performed for the primary tumor in 4 cases. Non-functioning: 7 cases (37%), insulinoma: 2 cases [1 with possible multiple endocrine neoplasia (MEN)], Zollinger-Ellison syndrome (ZES) from gastrinoma: 5 (3 with MEN-1), glucagonoma: 2 cases, 2 somatostatinomas; carcinoid: 1 case with carcinoide-like syndrome. Most patients were operated upon: 14/19 (73%). Four (4/14: 28%) has postoperative complications following pancreatectomy: pancreatitis, pseudocyst, and abdominal collections. Some patients received chemotherapy (4), somatostatin (3) and interferon (2) before or after surgery. Median follow-up was 48 months. Actuarial survival during the study was 73.6% (14/19). Conclusions: age was similar to that described in the literature. Males were predominant. Most cases were non-functioning (37%). Most patients underwent surgery (73%) with little morbidity (28%) and an actuarial survival of 73.6% at the time of the study. |
| first_indexed | 2024-12-23T14:40:56Z |
| format | Article |
| id | doaj.art-1b18e858cc1e484f981485d0c5a10a1e |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-12-23T14:40:56Z |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-1b18e858cc1e484f981485d0c5a10a1e2022-12-21T17:43:13ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01081034184190S1130-01082011000400003nasModesto Varas0Joan Gornals1José María Ponseti2Antonio Alastruè3Cristina Durán4Carlos Llevaria5Carlos Ballesta6Alberto Díez Caballero7Vicente Artigas8Centro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonCentro Médico TeknonIntroduction and objective: pancreatic endocrine tumors (PET) are difficult to diagnose. Their accurate localization using imaging techniques is intended to provide a definite cure. The goal of this retrospective study was to review a PET series from a private institution. Patients and methods: the medical records of 19 patients with PETs were reviewed, including 4 cases of MEN-1, for a period of 17 years (1994-2010). A database was set up with ten parameters: age, sex, symptoms, imaging techniques, size and location in the pancreas, metastasis, surgery, complications, adjuvant therapies, definite diagnosis, and survival or death. Results: a total of 19 cases were analyzed. Mean age at presentation was 51 years (range: 26-67 y) (14 males, 5 females), and tumor size was 5 to 80 mm (X: 20 mm). Metastatic disease was present in 37% (7/19). Most underwent the following imaging techniques: ultrasounds, computed tomography (CT) and magnetic resonance imaging (MRI). Fine needle aspiration punction (FNA) was performed for the primary tumor in 4 cases. Non-functioning: 7 cases (37%), insulinoma: 2 cases [1 with possible multiple endocrine neoplasia (MEN)], Zollinger-Ellison syndrome (ZES) from gastrinoma: 5 (3 with MEN-1), glucagonoma: 2 cases, 2 somatostatinomas; carcinoid: 1 case with carcinoide-like syndrome. Most patients were operated upon: 14/19 (73%). Four (4/14: 28%) has postoperative complications following pancreatectomy: pancreatitis, pseudocyst, and abdominal collections. Some patients received chemotherapy (4), somatostatin (3) and interferon (2) before or after surgery. Median follow-up was 48 months. Actuarial survival during the study was 73.6% (14/19). Conclusions: age was similar to that described in the literature. Males were predominant. Most cases were non-functioning (37%). Most patients underwent surgery (73%) with little morbidity (28%) and an actuarial survival of 73.6% at the time of the study.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082011000400003&lng=en&tlng=enTumores neuroendocrinos pancreáticos (TNEP) funcionantesInsulinomaSíndrome de Zollinger-Ellison (SZE)GlucagonomaSomatostatinomaVipomaCarcinoideNeoplasia endocrina múltiple (NEM)Secreción hormonal múltiple (SHM)Tumores no funcionantesUltrasonografía endoscópica (USE)PAAFSomatostatinaInterferónQuimioterapiaApudomas pancreáticos |
| spellingShingle | Modesto Varas Joan Gornals José María Ponseti Antonio Alastruè Cristina Durán Carlos Llevaria Carlos Ballesta Alberto Díez Caballero Vicente Artigas nas Revista Espanola de Enfermedades Digestivas Tumores neuroendocrinos pancreáticos (TNEP) funcionantes Insulinoma Síndrome de Zollinger-Ellison (SZE) Glucagonoma Somatostatinoma Vipoma Carcinoide Neoplasia endocrina múltiple (NEM) Secreción hormonal múltiple (SHM) Tumores no funcionantes Ultrasonografía endoscópica (USE) PAAF Somatostatina Interferón Quimioterapia Apudomas pancreáticos |
| title | nas |
| title_full | nas |
| title_fullStr | nas |
| title_full_unstemmed | nas |
| title_short | nas |
| title_sort | nas |
| topic | Tumores neuroendocrinos pancreáticos (TNEP) funcionantes Insulinoma Síndrome de Zollinger-Ellison (SZE) Glucagonoma Somatostatinoma Vipoma Carcinoide Neoplasia endocrina múltiple (NEM) Secreción hormonal múltiple (SHM) Tumores no funcionantes Ultrasonografía endoscópica (USE) PAAF Somatostatina Interferón Quimioterapia Apudomas pancreáticos |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082011000400003&lng=en&tlng=en |
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