CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1

CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1

Background/Aims: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE). Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a re...

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Bibliographic Details
Main Authors: Shu Li, Jingyi Xue, Zhipeng Sun, Tiantian Liu, Lane Zhang, Limin Wang, Hongjie You, Zheng Fan, Yuanyuan Zheng, Dali Luo
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
CaMKII
Store-operated Ca2+ entry
STIM1
Orai1
Online Access:https://www.karger.com/Article/FullText/488835

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