Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke
Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive deficits. There are important differences in the factors, clinical events and outcomes associated with the stroke in infants and adults. However, mechanisms unde...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2015-11-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500455 |
| _version_ | 1811304034770878464 |
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| author | Semyachkina-Glushkovskaya Oxana Sindeeva Olga Abdurashitov Arkady Sindeev Sergey Zinchenko Ekaterina Gekaluk Artem Ulanova Maria Mohanad Kassim Yankovskaya Ludmila Tuchin Valery |
| author_facet | Semyachkina-Glushkovskaya Oxana Sindeeva Olga Abdurashitov Arkady Sindeev Sergey Zinchenko Ekaterina Gekaluk Artem Ulanova Maria Mohanad Kassim Yankovskaya Ludmila Tuchin Valery |
| author_sort | Semyachkina-Glushkovskaya Oxana |
| collection | DOAJ |
| description | Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive deficits. There are important differences in the factors, clinical events and outcomes associated with the stroke in infants and adults. However, mechanisms underlying age differences in the stroke development remain largely unknown. Therefore, treatment guidelines for neonatal stroke must extrapolate from the adult data that is often not suitable for children. The new information about differences between neonatal and adult stroke is essential for identification of significant areas for future treatment and effective prevention of neonatal stroke. Here, we studied the development of stress-induced hemorrhagic stroke and possible mechanisms underlying these processes in newborn and adult rats. Using histological methods and magnetic resonance imaging, we found age differences in the type of intracranial hemorrhages. Newborn rats demonstrated small superficial bleedings in the cortex while adult rats had more severe deep bleedings in the cerebellum. Using Doppler optical coherent tomography, we found higher stress-reactivity of the sagittal sinus to deleterious effects of stress in newborn vs. adult rats suggesting that the cerebral veins are more vulnerable to negative stress factors in neonatal vs. adult brain in rats. However, adult but not newborn rats demonstrated the stroke-induced breakdown of blood brain barrier (BBB) permeability. The one of possible mechanisms underlying the higher resistance to stress-related stroke injures of cerebral vessels in newborn rats compared with adult animals is the greater expression of two main tight junction proteins of BBB (occludin and claudin-5) in neonatal vs. mature brain in rats. |
| first_indexed | 2024-04-13T07:58:42Z |
| format | Article |
| id | doaj.art-1b1f968853a54517af5f649e64a3d848 |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-13T07:58:42Z |
| publishDate | 2015-11-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-1b1f968853a54517af5f649e64a3d8482022-12-22T02:55:20ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052015-11-01861550045-11550045-1010.1142/S179354581550045510.1142/S1793545815500455Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic strokeSemyachkina-Glushkovskaya Oxana0Sindeeva Olga1Abdurashitov Arkady2Sindeev Sergey3Zinchenko Ekaterina4Gekaluk Artem5Ulanova Maria6Mohanad Kassim7Yankovskaya Ludmila8Tuchin Valery9Department of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Optics and Biophotonics, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Physiology of Human and Animals, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaDepartment of Therapy, Grodno Medical State University, Limozha Str. 23, Grodno 230005, ByelorussiaDepartment of Optics and Biophotonics, Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, RussiaNeonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive deficits. There are important differences in the factors, clinical events and outcomes associated with the stroke in infants and adults. However, mechanisms underlying age differences in the stroke development remain largely unknown. Therefore, treatment guidelines for neonatal stroke must extrapolate from the adult data that is often not suitable for children. The new information about differences between neonatal and adult stroke is essential for identification of significant areas for future treatment and effective prevention of neonatal stroke. Here, we studied the development of stress-induced hemorrhagic stroke and possible mechanisms underlying these processes in newborn and adult rats. Using histological methods and magnetic resonance imaging, we found age differences in the type of intracranial hemorrhages. Newborn rats demonstrated small superficial bleedings in the cortex while adult rats had more severe deep bleedings in the cerebellum. Using Doppler optical coherent tomography, we found higher stress-reactivity of the sagittal sinus to deleterious effects of stress in newborn vs. adult rats suggesting that the cerebral veins are more vulnerable to negative stress factors in neonatal vs. adult brain in rats. However, adult but not newborn rats demonstrated the stroke-induced breakdown of blood brain barrier (BBB) permeability. The one of possible mechanisms underlying the higher resistance to stress-related stroke injures of cerebral vessels in newborn rats compared with adult animals is the greater expression of two main tight junction proteins of BBB (occludin and claudin-5) in neonatal vs. mature brain in rats.http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500455Strokeage differencescerebral blood flowbrain blood barrier |
| spellingShingle | Semyachkina-Glushkovskaya Oxana Sindeeva Olga Abdurashitov Arkady Sindeev Sergey Zinchenko Ekaterina Gekaluk Artem Ulanova Maria Mohanad Kassim Yankovskaya Ludmila Tuchin Valery Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke Journal of Innovative Optical Health Sciences Stroke age differences cerebral blood flow brain blood barrier |
| title | Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke |
| title_full | Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke |
| title_fullStr | Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke |
| title_full_unstemmed | Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke |
| title_short | Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke |
| title_sort | blood brain barrier and cerebral blood flow age differences in hemorrhagic stroke |
| topic | Stroke age differences cerebral blood flow brain blood barrier |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545815500455 |
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