Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey
Background: Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression. Aims: To identify the relationships between clinicopatholo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2014-06-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=304 |
| _version_ | 1797905649952096256 |
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| author | Bülent Yıldız Evren Fidan Feyyaz Özdemir Orhan Sezen Halil Kavgacı Fazıl Aydın |
| author_facet | Bülent Yıldız Evren Fidan Feyyaz Özdemir Orhan Sezen Halil Kavgacı Fazıl Aydın |
| author_sort | Bülent Yıldız |
| collection | DOAJ |
| description | Background: Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression.
Aims: To identify the relationships between clinicopathological characteristics of TN breast cancers in the northeast region of Turkey and disease free survival (DFS) and overall survival (OS).
Study Design: Retrospective clinical study.
Methods: Seven hundred and eighty non-metastatic breast cancer patients were enrolled in this study. The relationships between TN breast cancer and other breast cancers with respect to clinicopathological characteristics, as well as DFS and OS, were studied.
Results: The triple-negative phenotype was detected in 204 patients (27.1%). Patients with triple-negative breast cancer had more grade 2-3 tumours compared to those with other types of breast cancer (92.5% versus 84.3%, p=0.004). Invasive ductal carcinoma histology, on the other hand, was less prevalent in patients with TN breast cancer (77% versus 84.5%, p=0.016). No significant differences were identified between the groups in other clinicopathological variables. Relapse and mortality rates were higher in the TN group during the follow-up of both groups [57 (27.9%) versus 89 (16.2%), p<0.001 for relapse; 27 (13.2%) versus 37 (6.8%), p=0.005 for mortality]. The univariate analysis demonstrated shorter DFS and OS for patients with TN breast cancer compared to those with other types of breast cancer. In the multivariate analysis, patients with TN breast cancer were 2.21 times more likely to develop relapse, while the likelihood of death increased 3.21-fold (p<0.001 and p<0.001).
Conclusion: Triple-negative breast cancers demonstrate a more aggressive clinical course compared to other breast cancers. More effective strategies should be developed for the treatment of this subgroup of breast cancer. |
| first_indexed | 2024-04-10T10:09:44Z |
| format | Article |
| id | doaj.art-1b2074b069f24d5babf32042b3ec7221 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T10:09:44Z |
| publishDate | 2014-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-1b2074b069f24d5babf32042b3ec72212023-02-15T16:22:16ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312014-06-0131212613110.5152/balkanmedj.2014.13143Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of TurkeyBülent Yıldız0Evren Fidan1Feyyaz Özdemir2Orhan Sezen3Halil Kavgacı4Fazıl Aydın5Department of Medical Oncology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, TurkeyDepartment of Medical Oncology, Konya Training and Research Hospital, Konya, TurkeyDepartment of Medical Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, TurkeyDepartment of Radiation Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, TurkeyDepartment of Medical Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, TurkeyDepartment of Medical Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, TurkeyBackground: Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression. Aims: To identify the relationships between clinicopathological characteristics of TN breast cancers in the northeast region of Turkey and disease free survival (DFS) and overall survival (OS). Study Design: Retrospective clinical study. Methods: Seven hundred and eighty non-metastatic breast cancer patients were enrolled in this study. The relationships between TN breast cancer and other breast cancers with respect to clinicopathological characteristics, as well as DFS and OS, were studied. Results: The triple-negative phenotype was detected in 204 patients (27.1%). Patients with triple-negative breast cancer had more grade 2-3 tumours compared to those with other types of breast cancer (92.5% versus 84.3%, p=0.004). Invasive ductal carcinoma histology, on the other hand, was less prevalent in patients with TN breast cancer (77% versus 84.5%, p=0.016). No significant differences were identified between the groups in other clinicopathological variables. Relapse and mortality rates were higher in the TN group during the follow-up of both groups [57 (27.9%) versus 89 (16.2%), p<0.001 for relapse; 27 (13.2%) versus 37 (6.8%), p=0.005 for mortality]. The univariate analysis demonstrated shorter DFS and OS for patients with TN breast cancer compared to those with other types of breast cancer. In the multivariate analysis, patients with TN breast cancer were 2.21 times more likely to develop relapse, while the likelihood of death increased 3.21-fold (p<0.001 and p<0.001). Conclusion: Triple-negative breast cancers demonstrate a more aggressive clinical course compared to other breast cancers. More effective strategies should be developed for the treatment of this subgroup of breast cancer.http://balkanmedicaljournal.org/text.php?lang=en&id=304Breast neoplasmsdisease free survivaloverall survival |
| spellingShingle | Bülent Yıldız Evren Fidan Feyyaz Özdemir Orhan Sezen Halil Kavgacı Fazıl Aydın Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey Balkan Medical Journal Breast neoplasms disease free survival overall survival |
| title | Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey |
| title_full | Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey |
| title_fullStr | Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey |
| title_full_unstemmed | Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey |
| title_short | Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey |
| title_sort | clinicopathological characteristics of triple negative breast cancers in the northeast region of turkey |
| topic | Breast neoplasms disease free survival overall survival |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=304 |
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