Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic.
An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3655982?pdf=render |
| _version_ | 1818500055696408576 |
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| author | Tadanobu Takahashi Jiasheng Song Takashi Suzuki Yoshihiro Kawaoka |
| author_facet | Tadanobu Takahashi Jiasheng Song Takashi Suzuki Yoshihiro Kawaoka |
| author_sort | Tadanobu Takahashi |
| collection | DOAJ |
| description | An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic. |
| first_indexed | 2024-12-10T20:37:51Z |
| format | Article |
| id | doaj.art-1b21411e5693443c9ce86bad8405da58 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T20:37:51Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1b21411e5693443c9ce86bad8405da582022-12-22T01:34:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6443910.1371/journal.pone.0064439Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic.Tadanobu TakahashiJiasheng SongTakashi SuzukiYoshihiro KawaokaAn influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic.http://europepmc.org/articles/PMC3655982?pdf=render |
| spellingShingle | Tadanobu Takahashi Jiasheng Song Takashi Suzuki Yoshihiro Kawaoka Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. PLoS ONE |
| title | Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. |
| title_full | Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. |
| title_fullStr | Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. |
| title_full_unstemmed | Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. |
| title_short | Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. |
| title_sort | mutations in na that induced low ph stability and enhanced the replication of pandemic h1n1 2009 influenza a virus at an early stage of the pandemic |
| url | http://europepmc.org/articles/PMC3655982?pdf=render |
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