Recent insights about pyrrolidine core skeletons in pharmacology
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1239658/full |
| _version_ | 1827823138567618560 |
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| author | Samet Poyraz H. Ali Döndaş H. Ali Döndaş Naciye Yaktubay Döndaş José M. Sansano |
| author_facet | Samet Poyraz H. Ali Döndaş H. Ali Döndaş Naciye Yaktubay Döndaş José M. Sansano |
| author_sort | Samet Poyraz |
| collection | DOAJ |
| description | To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015–2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance. |
| first_indexed | 2024-03-12T02:07:55Z |
| format | Article |
| id | doaj.art-1b21c64d4098409f8f100407dd0da132 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T02:07:55Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1b21c64d4098409f8f100407dd0da1322023-09-06T19:51:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-09-011410.3389/fphar.2023.12396581239658Recent insights about pyrrolidine core skeletons in pharmacologySamet Poyraz0H. Ali Döndaş1H. Ali Döndaş2Naciye Yaktubay Döndaş3José M. Sansano4Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova University, Adana, TürkiyeDepartment of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Çukurova University, Adana, TürkiyeDepartment of Biotechnology, Institute of Natural and Applied Sciences, Çukurova University, Adana, TürkiyeDepartment of Pharmacology, Faculty of Medicine, Çukurova University, Adana, TürkiyeDepartment of Organic Chemistry, Centro de Innovación en Química Avanzada (ORFEO-CINQA), Instituto de Síntesis Orgánica (ISO), University of Alicante, Alicante, SpainTo overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015–2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance.https://www.frontiersin.org/articles/10.3389/fphar.2023.1239658/fullpyrrolidinepyrrolidine 2,5-dionenatural productscytotoxicitypharmaceuticals |
| spellingShingle | Samet Poyraz H. Ali Döndaş H. Ali Döndaş Naciye Yaktubay Döndaş José M. Sansano Recent insights about pyrrolidine core skeletons in pharmacology Frontiers in Pharmacology pyrrolidine pyrrolidine 2,5-dione natural products cytotoxicity pharmaceuticals |
| title | Recent insights about pyrrolidine core skeletons in pharmacology |
| title_full | Recent insights about pyrrolidine core skeletons in pharmacology |
| title_fullStr | Recent insights about pyrrolidine core skeletons in pharmacology |
| title_full_unstemmed | Recent insights about pyrrolidine core skeletons in pharmacology |
| title_short | Recent insights about pyrrolidine core skeletons in pharmacology |
| title_sort | recent insights about pyrrolidine core skeletons in pharmacology |
| topic | pyrrolidine pyrrolidine 2,5-dione natural products cytotoxicity pharmaceuticals |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1239658/full |
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