Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration
Thyrotoxic hypokalemic periodic paralysis (THPP) is a disease characterized by recurrent episodes of muscle weakness due to intracellular potassium shifting in the presence of high levels of thyroid hormone. It occurs more commonly amongst young Asian men with underlying Graves’ disease. Attacks are...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2020-08-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/63/2/0091/ |
| _version_ | 1818305909060796416 |
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| author | Waraporn Polamaung Jaruwan Kongkit Parichat Yimnoi Patchaya Boonchaya-Anant Thiti Snabboon |
| author_facet | Waraporn Polamaung Jaruwan Kongkit Parichat Yimnoi Patchaya Boonchaya-Anant Thiti Snabboon |
| author_sort | Waraporn Polamaung |
| collection | DOAJ |
| description | Thyrotoxic hypokalemic periodic paralysis (THPP) is a disease characterized by recurrent episodes of muscle weakness due to intracellular potassium shifting in the presence of high levels of thyroid hormone. It occurs more commonly amongst young Asian men with underlying Graves’ disease. Attacks are commonly precipitated by ingestion of carbohydrate-rich meals or alcohols, stress or strenuous exercise. Herein, we describe an adult Thai man suffering from a hypokalemic periodic paralysis attack after receiving a dexamethasone injection. The diagnosis of Graves’ disease was confirmed by his thyroid function test and a presence of thyrotropin-receptor antibody. His weakness and hypokalemia responded well to potassium supplement and a non-selective beta blocker, while his thyrotoxicosis was initially controlled by an anti-thyroid medication and subsequently with a subtotal thyroidectomy. Clinicians should beware of this manifestation when administering steroids in the thyrotoxic patients, especially of Asian male descent. |
| first_indexed | 2024-12-13T06:34:04Z |
| format | Article |
| id | doaj.art-1b21cd33851645f1a3a3f46c6e287bfc |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-13T06:34:04Z |
| publishDate | 2020-08-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-1b21cd33851645f1a3a3f46c6e287bfc2022-12-21T23:56:33ZengKarolinum PressActa Medica1211-42861805-96942020-08-01632919310.14712/18059694.2020.2410072Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone AdministrationWaraporn PolamaungJaruwan KongkitParichat YimnoiPatchaya Boonchaya-AnantThiti SnabboonThyrotoxic hypokalemic periodic paralysis (THPP) is a disease characterized by recurrent episodes of muscle weakness due to intracellular potassium shifting in the presence of high levels of thyroid hormone. It occurs more commonly amongst young Asian men with underlying Graves’ disease. Attacks are commonly precipitated by ingestion of carbohydrate-rich meals or alcohols, stress or strenuous exercise. Herein, we describe an adult Thai man suffering from a hypokalemic periodic paralysis attack after receiving a dexamethasone injection. The diagnosis of Graves’ disease was confirmed by his thyroid function test and a presence of thyrotropin-receptor antibody. His weakness and hypokalemia responded well to potassium supplement and a non-selective beta blocker, while his thyrotoxicosis was initially controlled by an anti-thyroid medication and subsequently with a subtotal thyroidectomy. Clinicians should beware of this manifestation when administering steroids in the thyrotoxic patients, especially of Asian male descent.https://actamedica.lfhk.cuni.cz/63/2/0091/thyrotoxic periodic paralysishypokalemiasteroid-induceddexamethasone administration |
| spellingShingle | Waraporn Polamaung Jaruwan Kongkit Parichat Yimnoi Patchaya Boonchaya-Anant Thiti Snabboon Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration Acta Medica thyrotoxic periodic paralysis hypokalemia steroid-induced dexamethasone administration |
| title | Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration |
| title_full | Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration |
| title_fullStr | Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration |
| title_full_unstemmed | Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration |
| title_short | Thyrotoxic Hypokalemic Periodic Paralysis Triggered by Dexamethasone Administration |
| title_sort | thyrotoxic hypokalemic periodic paralysis triggered by dexamethasone administration |
| topic | thyrotoxic periodic paralysis hypokalemia steroid-induced dexamethasone administration |
| url | https://actamedica.lfhk.cuni.cz/63/2/0091/ |
| work_keys_str_mv | AT warapornpolamaung thyrotoxichypokalemicperiodicparalysistriggeredbydexamethasoneadministration AT jaruwankongkit thyrotoxichypokalemicperiodicparalysistriggeredbydexamethasoneadministration AT parichatyimnoi thyrotoxichypokalemicperiodicparalysistriggeredbydexamethasoneadministration AT patchayaboonchayaanant thyrotoxichypokalemicperiodicparalysistriggeredbydexamethasoneadministration AT thitisnabboon thyrotoxichypokalemicperiodicparalysistriggeredbydexamethasoneadministration |