Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography

Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography

Genetically encoded caged amino acids can be used to control the dynamics of protein activities and cellular localization in response to external cues. In the present study, we revealed the structural basis for the recognition of <i>O</i>-(2-nitrobenzyl)-L-tyrosine (<i>o</i>N...

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Bibliographic Details
Main Authors: Toshiaki Hosaka, Kazushige Katsura, Yoshiko Ishizuka-Katsura, Kazuharu Hanada, Kaori Ito, Yuri Tomabechi, Mio Inoue, Ryogo Akasaka, Chie Takemoto, Mikako Shirouzu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
nonnatural amino acid
cell-free protein synthesis
X-ray crystallography
caged amino acid
<i>O</i>-(2-nitrobenzyl)-L-tyrosine
Online Access:https://www.mdpi.com/1422-0067/23/18/10399

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