Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation
Abstract Background Maternal obesity is an emerging problem in the modern world. Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges. Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggr...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01349-w |
| _version_ | 1818282264858984448 |
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| author | Ta-Yu Liu Hong-Ren Yu Ching-Chou Tsai Li-Tung Huang Chih-Cheng Chen Jium-Ming Sheen Mao-Meng Tiao You-Lin Tain I-Chun Lin Yun-Ju Lai Yu-Ju Lin Te-Yao Hsu |
| author_facet | Ta-Yu Liu Hong-Ren Yu Ching-Chou Tsai Li-Tung Huang Chih-Cheng Chen Jium-Ming Sheen Mao-Meng Tiao You-Lin Tain I-Chun Lin Yun-Ju Lai Yu-Ju Lin Te-Yao Hsu |
| author_sort | Ta-Yu Liu |
| collection | DOAJ |
| description | Abstract Background Maternal obesity is an emerging problem in the modern world. Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges. Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggravate metabolic issues. Thus, the generational transmission of obesity is cyclical. Developing a strategy to prevent the occurrence of metabolic syndrome related to prenatal and/or postnatal HF diet is important. In this study, the reprogramming effects of maternal resveratrol treatment for the progeny with maternal HF/postnatal HF diets were investigated. Methods Sprague-Dawley dams were fed either a control or a high-fat/high sucrose diet (HFHS) from mating to lactation. After weaning, the progeny was fed chow or an HF diet. Four experimental groups were yielded: CC (maternal/postnatal control diet), HC (maternal HF/postnatal control diet), CH (maternal control/postnatal HFHS diet), and HH (maternal/postnatal HFHS diet). A fifth group (HRH) received a maternal HFHS diet plus maternal resveratrol treatment and a postnatal chow diet to study the effects of maternal resveratrol therapy. Results Maternal resveratrol treatment lessened the weight and adiposity of progeny that were programmed by combined prenatal and postnatal HFHS diets. Maternal resveratrol therapy ameliorated the decreased abundance of the sirtuin 1 (SIRT1) enzyme in retroperitoneal tissue and the altered leptin/soluble leptin receptor ratio of progeny. Maternal resveratrol therapy also decreased lipogenesis and increased lipolysis for progeny. Conclusions Maternal resveratrol intervention can prevent adiposity programmed by maternal and postnatal HFHS diets by inducing lipid metabolic modulation. This study offers a novel reprogramming role for the effect of maternal resveratrol supplements against obesity. |
| first_indexed | 2024-12-13T00:18:15Z |
| format | Article |
| id | doaj.art-1b2383cc1e89448bb624db0224b118eb |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T00:18:15Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-1b2383cc1e89448bb624db0224b118eb2022-12-22T00:05:42ZengBMCLipids in Health and Disease1476-511X2020-07-0119111310.1186/s12944-020-01349-wResveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulationTa-Yu Liu0Hong-Ren Yu1Ching-Chou Tsai2Li-Tung Huang3Chih-Cheng Chen4Jium-Ming Sheen5Mao-Meng Tiao6You-Lin Tain7I-Chun Lin8Yun-Ju Lai9Yu-Ju Lin10Te-Yao Hsu11Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial HospitalDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of MedicineDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial HospitalDepartment of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial HospitalAbstract Background Maternal obesity is an emerging problem in the modern world. Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges. Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggravate metabolic issues. Thus, the generational transmission of obesity is cyclical. Developing a strategy to prevent the occurrence of metabolic syndrome related to prenatal and/or postnatal HF diet is important. In this study, the reprogramming effects of maternal resveratrol treatment for the progeny with maternal HF/postnatal HF diets were investigated. Methods Sprague-Dawley dams were fed either a control or a high-fat/high sucrose diet (HFHS) from mating to lactation. After weaning, the progeny was fed chow or an HF diet. Four experimental groups were yielded: CC (maternal/postnatal control diet), HC (maternal HF/postnatal control diet), CH (maternal control/postnatal HFHS diet), and HH (maternal/postnatal HFHS diet). A fifth group (HRH) received a maternal HFHS diet plus maternal resveratrol treatment and a postnatal chow diet to study the effects of maternal resveratrol therapy. Results Maternal resveratrol treatment lessened the weight and adiposity of progeny that were programmed by combined prenatal and postnatal HFHS diets. Maternal resveratrol therapy ameliorated the decreased abundance of the sirtuin 1 (SIRT1) enzyme in retroperitoneal tissue and the altered leptin/soluble leptin receptor ratio of progeny. Maternal resveratrol therapy also decreased lipogenesis and increased lipolysis for progeny. Conclusions Maternal resveratrol intervention can prevent adiposity programmed by maternal and postnatal HFHS diets by inducing lipid metabolic modulation. This study offers a novel reprogramming role for the effect of maternal resveratrol supplements against obesity.http://link.springer.com/article/10.1186/s12944-020-01349-wMaternal resveratrolReprogramsPrenatalPostnatalHigh-fat dietAdiposity |
| spellingShingle | Ta-Yu Liu Hong-Ren Yu Ching-Chou Tsai Li-Tung Huang Chih-Cheng Chen Jium-Ming Sheen Mao-Meng Tiao You-Lin Tain I-Chun Lin Yun-Ju Lai Yu-Ju Lin Te-Yao Hsu Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation Lipids in Health and Disease Maternal resveratrol Reprograms Prenatal Postnatal High-fat diet Adiposity |
| title | Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation |
| title_full | Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation |
| title_fullStr | Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation |
| title_full_unstemmed | Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation |
| title_short | Resveratrol intake during pregnancy and lactation re-programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high-fat/high sucrose plus postnatal high-fat/high sucrose diets via fat metabolism regulation |
| title_sort | resveratrol intake during pregnancy and lactation re programs adiposity and ameliorates leptin resistance in male progeny induced by maternal high fat high sucrose plus postnatal high fat high sucrose diets via fat metabolism regulation |
| topic | Maternal resveratrol Reprograms Prenatal Postnatal High-fat diet Adiposity |
| url | http://link.springer.com/article/10.1186/s12944-020-01349-w |
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