A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania
This work was aimed at correlating the chemotype of three Mentha species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were Mentha piperita L. var. pallescens (white peppermint), Mentha spicata L. subsp. crisp...
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/2/263 |
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| author | Cristina Mogosan Oliviu Vostinaru Radu Oprean Codruta Heghes Lorena Filip Georgeta Balica Radu Ioan Moldovan |
| author_facet | Cristina Mogosan Oliviu Vostinaru Radu Oprean Codruta Heghes Lorena Filip Georgeta Balica Radu Ioan Moldovan |
| author_sort | Cristina Mogosan |
| collection | DOAJ |
| description | This work was aimed at correlating the chemotype of three Mentha species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were Mentha piperita L. var. pallescens (white peppermint), Mentha spicata L. subsp. crispata (spearmint), and Mentha suaveolens Ehrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selected Mentha species was performed by gas chromatography coupled with mass spectrometry (GC-MS). The anti-inflammatory activity of the essential oils was determined by the rat paw edema test induced by λ-carrageenan. The antinociceptive effect of the essential oils was evaluated by the writhing test in mice, using 1% (v/v) acetic acid solution administered intraperitonealy and by the hot plate test in mice. The results showed a menthol chemotype for M. piperita pallescens, a carvone chemotype for M. spicata, and a piperitenone oxide chemotype for M. suaveolens. The essential oil from M. spicata L. (EOMSP) produced statistically significant and dose-dependent anti-inflammatory and antinociceptive effects. |
| first_indexed | 2024-04-12T11:21:56Z |
| format | Article |
| id | doaj.art-1b26e30e4cd446189ee4e82c1db21d15 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T11:21:56Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1b26e30e4cd446189ee4e82c1db21d152022-12-22T03:35:20ZengMDPI AGMolecules1420-30492017-02-0122226310.3390/molecules22020263molecules22020263A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in RomaniaCristina Mogosan0Oliviu Vostinaru1Radu Oprean2Codruta Heghes3Lorena Filip4Georgeta Balica5Radu Ioan Moldovan6Department of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, RomaniaDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, RomaniaDepartment of Analytical Chemistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, RomaniaDepartment of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, RomaniaDepartment of Bromatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, RomaniaDepartment of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400337, RomaniaSC Fares Biovital Laboratories SRL, Orastie 335700, RomaniaThis work was aimed at correlating the chemotype of three Mentha species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were Mentha piperita L. var. pallescens (white peppermint), Mentha spicata L. subsp. crispata (spearmint), and Mentha suaveolens Ehrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selected Mentha species was performed by gas chromatography coupled with mass spectrometry (GC-MS). The anti-inflammatory activity of the essential oils was determined by the rat paw edema test induced by λ-carrageenan. The antinociceptive effect of the essential oils was evaluated by the writhing test in mice, using 1% (v/v) acetic acid solution administered intraperitonealy and by the hot plate test in mice. The results showed a menthol chemotype for M. piperita pallescens, a carvone chemotype for M. spicata, and a piperitenone oxide chemotype for M. suaveolens. The essential oil from M. spicata L. (EOMSP) produced statistically significant and dose-dependent anti-inflammatory and antinociceptive effects.http://www.mdpi.com/1420-3049/22/2/263Mentha spp.mentholcarvonepiperitenone oxideanti-inflammatoryantinociceptive |
| spellingShingle | Cristina Mogosan Oliviu Vostinaru Radu Oprean Codruta Heghes Lorena Filip Georgeta Balica Radu Ioan Moldovan A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania Molecules Mentha spp. menthol carvone piperitenone oxide anti-inflammatory antinociceptive |
| title | A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania |
| title_full | A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania |
| title_fullStr | A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania |
| title_full_unstemmed | A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania |
| title_short | A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania |
| title_sort | comparative analysis of the chemical composition anti inflammatory and antinociceptive effects of the essential oils from three species of mentha cultivated in romania |
| topic | Mentha spp. menthol carvone piperitenone oxide anti-inflammatory antinociceptive |
| url | http://www.mdpi.com/1420-3049/22/2/263 |
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