Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

Human neutrophil elastase (HNE) is involved in a number of essential physiological processes and has been identified as a potential therapeutic target for treating acute and chronic lung injury. Nevertheless, only one drug, Sivelestat, has been approved for clinical use and just in Japan and the Rep...

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Bibliographic Details
Main Authors: Letizia Crocetti, Maria Paola Giovannoni, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Chemistry
Subjects:
human neutrophil elastase
inhibitor
Sivelestat
stability
molecular modeling
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00795/full

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