Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into th...
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| Format: | Article |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.567394/full |
| _version_ | 1819074627707600896 |
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| author | Bill Qi Kellie MacDonald Marcelo T. Berlim Allan Fielding Eric Lis Nancy Low Stéphane Richard-Devantoy Valerie Tourjman Gustavo Turecki Yannis Trakadis Yannis Trakadis |
| author_facet | Bill Qi Kellie MacDonald Marcelo T. Berlim Allan Fielding Eric Lis Nancy Low Stéphane Richard-Devantoy Valerie Tourjman Gustavo Turecki Yannis Trakadis Yannis Trakadis |
| author_sort | Bill Qi |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression—Adult (n = 66, 58, 60, for low, medium, high severity, respectively). We saw a significant and gradual increase in the frequency of “muscular paralysis” (1.5–5.2–16.7%) and “balance problems” (21.2–36.2–46.6%) from low to medium to high severity groups. We repeated the analysis using only the two most extreme severity categories: low severity (66 samples) vs. high severity (60 samples). High severity patients were also found to experience more “angina” symptoms than low severity patients (27.3 vs. 50%). The three significant clinical variables identified were introduced into a binary logistic regression model as the independent variables with high or low severity as the dependent variable. Both “muscular paralysis” and “balance problems” were significantly associated with increased severity of depression (odds ratio of 13.5 and 2.9, respectively), while “angina” was associated with an increase in severity with an odds ratio of 2.0, albeit not significantly. We show that neurological exam or clinical history could be useful biomarkers for depression severity. Our findings, if replicated, could lead to a simple clinical scale administered regularly for monitoring patients with MDD. |
| first_indexed | 2024-12-21T18:12:32Z |
| format | Article |
| id | doaj.art-1b278d08c83a477ba7bd3fd74413814f |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T18:12:32Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-1b278d08c83a477ba7bd3fd74413814f2022-12-21T18:54:44ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-12-011110.3389/fpsyt.2020.567394567394Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major DepressionBill Qi0Kellie MacDonald1Marcelo T. Berlim2Allan Fielding3Eric Lis4Nancy Low5Stéphane Richard-Devantoy6Valerie Tourjman7Gustavo Turecki8Yannis Trakadis9Yannis Trakadis10Department of Human Genetics, McGill University, Montreal, QC, CanadaDepartment of Human Genetics, McGill University, Montreal, QC, CanadaNeuromodulation Research Clinic, Depressive Disorders Program, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaDepartment of Psychiatry, McGill University, Montreal, QC, CanadaMcGill University Psychiatry Perceptions of Emerging Technologies Labs, Montreal, QC, CanadaDepartment of Psychiatry, McGill University, Montreal, QC, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaInstitut Universitaire en Santé Mentale de Montréal, Montreal, QC, CanadaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, CanadaDepartment of Human Genetics, McGill University, Montreal, QC, CanadaDepartment of Medical Genetics, McGill University Health Center, Montreal, QC, CanadaMajor depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression—Adult (n = 66, 58, 60, for low, medium, high severity, respectively). We saw a significant and gradual increase in the frequency of “muscular paralysis” (1.5–5.2–16.7%) and “balance problems” (21.2–36.2–46.6%) from low to medium to high severity groups. We repeated the analysis using only the two most extreme severity categories: low severity (66 samples) vs. high severity (60 samples). High severity patients were also found to experience more “angina” symptoms than low severity patients (27.3 vs. 50%). The three significant clinical variables identified were introduced into a binary logistic regression model as the independent variables with high or low severity as the dependent variable. Both “muscular paralysis” and “balance problems” were significantly associated with increased severity of depression (odds ratio of 13.5 and 2.9, respectively), while “angina” was associated with an increase in severity with an odds ratio of 2.0, albeit not significantly. We show that neurological exam or clinical history could be useful biomarkers for depression severity. Our findings, if replicated, could lead to a simple clinical scale administered regularly for monitoring patients with MDD.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.567394/fullbiomarkersdepressionseveritysymptomsstratification |
| spellingShingle | Bill Qi Kellie MacDonald Marcelo T. Berlim Allan Fielding Eric Lis Nancy Low Stéphane Richard-Devantoy Valerie Tourjman Gustavo Turecki Yannis Trakadis Yannis Trakadis Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression Frontiers in Psychiatry biomarkers depression severity symptoms stratification |
| title | Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression |
| title_full | Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression |
| title_fullStr | Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression |
| title_full_unstemmed | Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression |
| title_short | Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression |
| title_sort | balance problems paralysis and angina as clinical markers for severity in major depression |
| topic | biomarkers depression severity symptoms stratification |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.567394/full |
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